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Superantibodies
Antibody term is used for the molecule that binds the antigen at the cell surface or outside the cell. But when the antibody binds to molecule within the cell, the term superantibody is coined by Heinz Kohler and Sudhir Paul in 1998. The superantibody is able to cross the cell membrane of each cell but get accumalated only where the target antigen is present. What are superantibodies ?As the superantibody can cross the cell barrier, this ablity to cross is genrally provided by cell penetrating peptide attached near the CDR region of the antibody. The superantibody can be able to play an important role in the recognition of antigen present inside the cell.Production of superantibodiesThis modification is a short protein segment, normally found in signalling proteins such as growth factors that can enter cells.The scientists found that the super antibody enters all cells but only builds up in those cells it has been primed to target. Uses of superantibodiesThe scientists found that the super antibody enters all cells b Charles Morgan, president of InNexus Biotechnology, said: "Most good targets for diseases are inside cells."Some experts say the market for super antibodies could reach about $15 billion a year. The scientists say that these super antibodies could perhaps target such cells as HIV and destroy them. It could be primed to attack virtually any type of cell. |