References for PCMdb

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S. No. Title PMID
1Preliminary study analyzing the methylated genes in the plasma of patients with pancreatic cancer.22414467
2Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma.22293850
3Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas.22173550
4Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro.21987623
5Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma.21610144
6Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.21572398
7Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines.21269942
8SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma.20939879
9DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.20926598
10Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells.20173668
11Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion.19893036
12Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.19223499
13Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.19035457
14DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease.18995218
15Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas.18820670
16Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma.18535405
17Hypermethylation and aberrant expression of secreted frizzled-related protein genes in pancreatic cancer.18528941
18Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases.18492726
19Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer.18475302
20MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells.18413738
21Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.18223216
22CpG island methylation profile of pancreatic intraepithelial neoplasia.18157091
23Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines.17895890
24Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.17675336
25DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.16537562
26Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.16479257
27DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease.16424060
28Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis.16258509
29Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.15985168
30Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms.15970691
31The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer.15662133
32Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types.15383627
33Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer.15289340
34Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.15121754
35The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.15073125
36Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia.14871978
37CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.14645499
38Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.14614047
39Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms.14501508
40Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.12874021
41Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms.12865927
42Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.12839967
43O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme.12684420
44Significance of thymidylate synthase activity in renal cell carcinoma.12684419
45Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues.12684418
46Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice.12673124
47Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.12651607
48Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors.12629131
49Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions.12610506
50Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.12591989
51Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas.12584167
52Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs.12432281
53Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.12000709
54Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors.11965547
55Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived.11960385
56Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation.11786397
57p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb.11753042
58Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.11731440
59Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors.11479232
60The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein.11420696
61Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.11306499
62Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas.11095446
63Hypermethylation of multiple genes in pancreatic adenocarcinoma.10766168
64Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.10644993
65Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.10029064
66Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation.9443399
67Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.9242437
68zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells.10495427
69Low frequency of p16(INK4a) alterations in insulinomas.11025365
70p16(INK4a) alterations in chronic pancreatitis-indicator for high-risk lesions for pancreatic cancer.11283541
71De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation.11893907
72Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas.12105864
73Tumor-suppressing pathways in cystic pancreatic tumors.12499916
74Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.12527896
75Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.12527922
76CpG island methylation in carcinoid and pancreatic endocrine tumors.12584572
77Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.12802288
78Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters.12898359
79SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions.12902985
80Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms.14668721
81Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling.14716296
82Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines.14743205
83Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer.15245595
84Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers.15467763
85Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas.15714128
86Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.15824892
87Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression.15870692
88Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.15942716
89Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing.16112420
90Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers.16472607
91E-cadherin and DAP kinase in pancreatic adenocarcinoma and corresponding lymph node metastases.16596173
92Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms.16670620
93MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer.16721789
94Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma.16988769
95Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours.17803708
96Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells.18394600
97Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer.18437076
98Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma.19170121
99Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation.19465885
100Characterizing DNA methylation patterns in pancreatic cancer genome.19497796
101High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers.20394502
102Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.20428826
103Methylation-mediated silencing of TMS1 in pancreatic cancer and its potential contribution to chemosensitivity.21036703
104Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array).21723258
105The role of quantitative NPTX2 hypermethylation as a novel serum diagnostic marker in pancreatic cancer.21778928
106Aberrant methylation of RASSF2A in human pancreatic ductal adenocarcinoma and its relation to clinicopathologic features.21792082
107Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer.22552606
108Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers.22806544
109Site- and grade-specific diversity of LINE1 methylation pattern in gastroenteropancreatic neuroendocrine tumours.22993308
110SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling.23318427

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