ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
---|---|---|---|---|---|---|---|---|---|---|
ASPsiRNA ID | Mutant allele/ASP-siRNA | Efficacy for mutant(%) |
Efficacy for wild (%) |
Relative Difference (%) | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
aspsirna0556 | CAGAGUGGCU---GAGAUGAC GUCUCACCGA---CUCUACUG |
80 | 45 | 35 | TOR1A | DYT1 dystonia | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0557 | CU---GAGAUGACAUUUUUCCCC GA---CUCUACUGUAAAAAGGGG |
4 | 15 | -11 | TOR1A | DYT1 dystonia | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0558 | GAGUGGCU---GAGAUGACAUUUUUC CUCACCGA---CUCUACUGUAAAAAG |
0 | 27 | -27 | TOR1A | DYT1 dystonia | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0895 | AGCAGAGUGGCUGAG---AUGA UCGUCUCACCGACUC---UACU |
46 | 5 | 41 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0896 | GCAGAGUGGCUGAG---AUGAC CGUCUCACCGACUC---UACUG |
67 | 52 | 15 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0897 | AAGCAGAGUGGCUGAGGAG UUCGUCUCACCGACUCCUC |
74 | 70 | 4 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0898 | AGCAGAGUGGCUGAGGAGA UCGUCUCACCGACUCCUCU |
56 | 34 | 22 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0923 | GAGUGGCUGAG---AUGACAUU CUCACCGACUC---UACUGUAA |
92 | 58 | 34 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0924 | GUGGCUGAG---AUGACAUUUU CACCGACUC---UACUGUAAAA |
85 | 19 | 66 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0925 | GUGGCUGAG---AUGACAUUUU CACCGACUC---UACUGUAAAA |
90 | 12 | 78 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0926 | GUGGCUGAG---AUGACAUUUU CACCGACUC---UACUGUAAAA |
NA | NA | NA | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna0927 | CAGAGUGGCUGAG---AUGACA GUCUCACCGACUC---UACUGU |
95 | 15 | 80 | TOR1A | Early onset torsion dystonia (DYT1) | c.907_909delGAG,p.Glu303del | rs72415998 | ||
aspsirna3555 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
70 | 68 | 2 | TOR1A | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | NA | NA | ||
aspsirna3556 | GUGGCCACAUGGAAGUAAAAUC CACCGGUGUACCUUCAUUUUAG |
55 | 0 | 55 | TOR1A | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | NA | NA | ||
aspsirna3557 | GUGGCCAGAUGCAAGUAAAAUC CACCGGUCUACGUUCAUUUUAG |
59 | 10 | 49 | TOR1A | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | NA | NA |