Total number of Results for US20080176812A1 are 30
ASPsiRNA ID Pairing of target region (top) and ASP-siRNA (bottom) Efficacy (mut)(%) Efficacy (wt) (%) Diff Gene Disease Mutation RefSNP Analysis Pubmed ID
ASPsiRNA ID Mutant allele/ASP-siRNA Efficacy
for mutant(%)		 Efficacy
for wild (%)		 Relative Difference (%) Gene Disease Mutation RefSNP Analysis Pubmed ID
aspsirna3528 CAGCAGCAGCGGGACCUAUC
GUCGUCGUCGCCCUGGAUAG		 66 62 4 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3529 CAGCAGCCGGACCUAUCAGGAC
GUCGUCGGCCUGGAUAGUCCUG		 80 20 60 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3530 CAGCAGCGGGACCUAUCAGGAC
GUCGUCGCCCUGGAUAGUCCUG		 55 0 55 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3531 CAGCAGCAGGGGGACCUAUC
GUCGUCGUCCCCCUGGAUAG		 40 22 18 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3532 UUGAAAAACAGCAGCAAAAGC
AACUUUUUGUCGUCGUUUUCG		 65 20 45 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3533 CAGCAGCAGCAGCAGCAGCAGC
GUCGUCGUCGUCGUCGUCGUCG		 46 NA NA ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3534 CAGCCGGGAGUCGGGAAGGUGC
GUCGGCCCUCAGCCCUUCCACG		 43 NA NA MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3535 ACGUCCUCGGCGGCGGCAGUGUGC
UGCAGGAGCCGCCGCCGUCACACG		 80 NA NA MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3536 ACGUCUCCAUGGCAUCUCAGC
UGCAGAGGUACCGUAGAGUCG		 17 85 -68 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3537 GUGGCCAGAUGGAAGUAAAAUC
CACCGGUCUACCUUCAUUUUAG		 65 60 5 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3538 GUGGCCACAUGGAAGUAAAAUC
CACCGGUGUACCUUCAUUUUAG		 65 0 65 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3539 GUGGCCAGAUGCAAGUAAAAUC
CACCGGUCUACGUUCAUUUUAG		 28 55 -27 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3540 CAGCAGCAGCGGGACCUAUC
GUCGUCGUCGCCCUGGAUAG		 66 62 4 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3541 CAGCAGCCGGACCUAUCAGGAC
GUCGUCGGCCUGGAUAGUCCUG		 80 20 60 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3542 CAGCAGCGGGACCUAUCAGGAC
GUCGUCGCCCUGGAUAGUCCUG		 55 0 55 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3543 CAGCAGCAGGGGGACCUAUC
GUCGUCGUCCCCCUGGAUAG		 40 22 18 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3544 UUGAAAAACAGCAGCAAAAGC
AACUUUUUGUCGUCGUUUUCG		 65 20 45 ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3545 CAGCAGCAGCAGCAGCAGCAGC
GUCGUCGUCGUCGUCGUCGUCG		 46 NA NA ATXN3 Machado-Joseph Disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) c.G987C,c.892_894CAG(8_36) (p.Gln298_Gln305=) rs19392292
US20080176812A1
aspsirna3546 CAGCCGGGAGUCGGGAAGGUGC
GUCGGCCCUCAGCCCUUCCACG		 43 NA NA MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3547 ACGUCCUCGGCGGCGGCAGUGUGC
UGCAGGAGCCGCCGCCGUCACACG		 80 NA NA MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3548 ACGUCUCCAUGGCAUCUCAGC
UGCAGAGGUACCGUAGAGUCG		 17 85 -68 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3549 GUGGCCAGAUGGAAGUAAAAUC
CACCGGUCUACCUUCAUUUUAG		 65 60 5 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3550 GUGGCCACAUGGAAGUAAAAUC
CACCGGUGUACCUUCAUUUUAG		 65 0 65 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3551 GUGGCCAGAUGCAAGUAAAAUC
CACCGGUCUACGUUCAUUUUAG		 28 55 -27 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3552 GUGGCCAGAUGGAAGUAAAAUC
CACCGGUCUACCUUCAUUUUAG		 70 68 2 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3553 GUGGCCACAUGGAAGUAAAAUC
CACCGGUGUACCUUCAUUUUAG		 55 0 55 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3554 GUGGCCAGAUGCAAGUAAAAUC
CACCGGUCUACGUUCAUUUUAG		 59 10 49 MAPT Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) c.1960G>A,p.Val654Met rs63750570
US20080176812A1
aspsirna3555 GUGGCCAGAUGGAAGUAAAAUC
CACCGGUCUACCUUCAUUUUAG		 70 68 2 TOR1A Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) NA NA
US20080176812A1
aspsirna3556 GUGGCCACAUGGAAGUAAAAUC
CACCGGUGUACCUUCAUUUUAG		 55 0 55 TOR1A Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) NA NA
US20080176812A1
aspsirna3557 GUGGCCAGAUGCAAGUAAAAUC
CACCGGUCUACGUUCAUUUUAG		 59 10 49 TOR1A Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) NA NA
US20080176812A1