Amino Acid Polarity Hydrophobic Hydrophilic
3(60 %) 2 (40 %)

Amino Acid Charge+vely charged-vely chargedNeutral Amino acid
1(20 %)0(0 %)4 (80 %)

Amino Acid Surface exposureSurface exposedBurried
2(40 %)3 (60 %)

DisorderDisorder-promotingOrder-promotingDisorder-order neutral
3(60 %)2(40 %)0 (0 %)

FlexibilityHighly flexibilityLow flexibility
2(40 %)3 (60 %)


Charge
VSAFK
P+veN-veO No chargeN
Polarity
VSAFK
PHydrophobicNhydrophilic



Numerical values of physicochemical properties are based on AAindex database (Kawashima et al. 2008)