Browsing by Chemical modifications

This page lists the various C-terminal modifications, N-terminal modifications as well as the chemical modifications that were incorporated in the anticancer peptides compiled in CancerPPD. For more information see Help

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C-ter modification
N-ter modification
Chemical modifications

C-ter Modifications Number of entries

Amidation 1957

Fluoromethyl ketone(fmk) 3

Free 1519

Methoxylation 3

N-ter modifications Number of entries

Acetylation 30

Beta-alanine 32

Biotinylated 65

CH3(CH2)10CO 2

CH3(CH2)12CO 2

CH3(CH2)14CO 2

Dextran 2

Free 3344

Chemical Modifications Number of entries

(2,2-di(4-[trifluoromethyl]benzyl)-3-amino-propionic acid) 8

(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid) 8

A* = Cα -dialkylated glycine (Aaa2,2 ) 120

A* = Cαα -dialkylated glycine (Aaa1,1 ) 63

A*=Lanthionine bridge between Alanine 6

AC6C = cyclohexyl-1-carboxylic acid 9

Ade = 3-aminodecanoyl, Hleu =hydroxyleucyl, Hasn = hydoxyasparaginyl 7

Aib = 1-amino-isobutyric acid 6

Aib = 1-amino-isobutyric acid ,Pac = Paclitaxel 9

Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine
or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen 24

Anthranilic acid 1

Aoc = 3-aminooctanoic acid ,Hyp = 4- hydroxyproline, Dhb = didehydrobutyrine, Hse = Homoserine 3

Dextran 2

Dip = diphenylalanine 10

Dip = diphenylalanine, O=ornithine 3

Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ] 8

Nal = 3-(1-naphthyl)alanine 3

O = Ornithine 6

Pem= Pemetrexed 6