Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MLH1	AGISFSVKN	ENDOMETRIUM	188	p.K195fs	c.583_583delA	Frame_Shift_Del	1	0.11	HEC265	N	0	0	0	N
MLH1	AHTFCLLNI	KIDNEY	725	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	Y	3	13	0	N
MLH1	AYRASSQME	LARGE_INTESTINE	125	p.Y130fs	c.389_389delA	Frame_Shift_Del	4	0.11	CW2	N	0	0	0	N
MLH1	CAHTFCLLN	KIDNEY	724	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	1	0	0	N
MLH1	CAYRASSQM	LARGE_INTESTINE	124	p.Y130fs	c.389_389delA	Frame_Shift_Del	3	0.11	CW2	N	8	0	0	N
MLH1	CLIYTKSLR	KIDNEY	746	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	5	0	0	N
MLH1	CLLNISQKM	KIDNEY	729	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	5	0	0	N
MLH1	CSLLTCLIY	KIDNEY	741	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	6	0	0	N
MLH1	DNIRSIFGM	ENDOMETRIUM	214	p.G221fs	c.663_663delA	Frame_Shift_Del	1	0.11	HEC6	N	4	0	0	N
MLH1	EISCSLLTC	KIDNEY	738	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	1	0	0	N
MLH1	FCLLNISQK	KIDNEY	728	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	5	0	6	N
MLH1	FSVKNKERQ	ENDOMETRIUM	192	p.K195fs	c.583_583delA	Frame_Shift_Del	5	0.11	HEC265	N	2	0	6	N
MLH1	GISFSVKNK	ENDOMETRIUM	189	p.K195fs	c.583_583delA	Frame_Shift_Del	2	0.11	HEC265	Y	2	12	0	N
MLH1	GKCAYRASS	LARGE_INTESTINE	122	p.Y130fs	c.389_389delA	Frame_Shift_Del	1	0.11	CW2	N	1	0	0	N
MLH1	GLWNTLSIK	KIDNEY	714	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	6	0	0	N
MLH1	GSGLWNTLS	KIDNEY	712	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	0	0	0	N
MLH1	GSIPNSGSG	KIDNEY	706	p.S711fs	c.2132_2132delC	Frame_Shift_Del	3	0.11	SNU349	N	1	0	0	N
MLH1	HTFCLLNIS	KIDNEY	726	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	0	0	0	N
MLH1	IFGMLLVEN	ENDOMETRIUM	219	p.G221fs	c.663_663delA	Frame_Shift_Del	5	0.11	HEC6	N	0	0	0	N
MLH1	IKPCAHTFC	KIDNEY	721	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	1	0	0	N
MLH1	IPNSGSGLW	KIDNEY	708	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	6	0	0	N
MLH1	IRSIFGMLL	ENDOMETRIUM	216	p.G221fs	c.663_663delA	Frame_Shift_Del	3	0.11	HEC6	Y	10	9	20	N
MLH1	ISCSLLTCL	KIDNEY	739	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	13	0	0	N
MLH1	ISFSVKNKE	ENDOMETRIUM	190	p.K195fs	c.583_583delA	Frame_Shift_Del	3	0.11	HEC265	N	0	0	1	N
MLH1	ISQKMEISC	KIDNEY	733	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	1	0	0	N
MLH1	IYTKSLRGV	KIDNEY	748	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	3	0	14	N
MLH1	KCAYRASSQ	LARGE_INTESTINE	123	p.Y130fs	c.389_389delA	Frame_Shift_Del	2	0.11	CW2	N	0	0	0	N
MLH1	KMEISCSLL	KIDNEY	736	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	12	0	0	N
MLH1	KPCAHTFCL	KIDNEY	722	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	17	0	0	N
MLH1	LIYTKSLRG	KIDNEY	747	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	0	0	9	N
MLH1	LLNISQKME	KIDNEY	730	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	0	0	1	N
MLH1	LLTCLIYTK	KIDNEY	743	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	6	0	2	N
MLH1	LNISQKMEI	KIDNEY	731	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	7	0	35	N
MLH1	LSIKPCAHT	KIDNEY	719	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	1	0	4	N
MLH1	LTCLIYTKS	KIDNEY	744	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	1	0	0	N
MLH1	LWNTLSIKP	KIDNEY	715	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	0	0	0	N
MLH1	MEISCSLLT	KIDNEY	737	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	6	0	7	N
MLH1	NIRSIFGML	ENDOMETRIUM	215	p.G221fs	c.663_663delA	Frame_Shift_Del	2	0.11	HEC6	N	8	0	0	N
MLH1	NISQKMEIS	KIDNEY	732	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	0	0	0	N
MLH1	NSGSGLWNT	KIDNEY	710	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	2	0	0	N
MLH1	NTLSIKPCA	KIDNEY	717	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	1	0	0	N
MLH1	PCAHTFCLL	KIDNEY	723	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	0	0	0	N
MLH1	PGSIPNSGS	KIDNEY	705	p.S711fs	c.2132_2132delC	Frame_Shift_Del	2	0.11	SNU349	N	0	0	0	N
MLH1	PNSGSGLWN	KIDNEY	709	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	0	0	0	N
MLH1	QKMEISCSL	KIDNEY	735	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	8	0	0	N
MLH1	RRIINLTVF	OVARY	498	p.S505fs	c.1513_1513delA	Frame_Shift_Del	2	0.11	IGROV1	N	8	0	0	N
MLH1	RRRIINLTV	OVARY	497	p.S505fs	c.1513_1513delA	Frame_Shift_Del	1	0.11	IGROV1	N	3	0	0	N
MLH1	RSIFGMLLV	ENDOMETRIUM	217	p.G221fs	c.663_663delA	Frame_Shift_Del	4	0.11	HEC6	Y	5	11	0	N
MLH1	SCSLLTCLI	KIDNEY	740	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	2	0	0	N
MLH1	SFSVKNKER	ENDOMETRIUM	191	p.K195fs	c.583_583delA	Frame_Shift_Del	4	0.11	HEC265	N	2	0	0	N
MLH1	SGLWNTLSI	KIDNEY	713	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	9	0	0	N
MLH1	SGSGLWNTL	KIDNEY	711	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	Y	11	10	0	N
MLH1	SIFGMLLVE	ENDOMETRIUM	218	p.G221fs	c.663_663delA	Frame_Shift_Del	5	0.11	HEC6	N	0	0	0	N
MLH1	SIKPCAHTF	KIDNEY	720	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	Y	4	9	0	N
MLH1	SIPNSGSGL	KIDNEY	707	p.S711fs	c.2132_2132delC	Frame_Shift_Del	4	0.11	SNU349	N	7	0	0	N
MLH1	SLLTCLIYT	KIDNEY	742	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	4	0	0	N
MLH1	SQKMEISCS	KIDNEY	734	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	1	0	0	N
MLH1	TCLIYTKSL	KIDNEY	745	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	7	0	0	N
MLH1	TFCLLNISQ	KIDNEY	727	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	0	0	0	N
MLH1	TLSIKPCAH	KIDNEY	718	p.S711fs	c.2132_2132delC	Frame_Shift_Del	5	0.11	SNU349	N	0	0	0	N
MLH1	VPGSIPNSG	KIDNEY	704	p.S711fs	c.2132_2132delC	Frame_Shift_Del	1	0.11	SNU349	N	2	0	0	N
MLH1	WNTLSIKPC	KIDNEY	716	p.S711fs	c.2132_2132delC	Frame_Shift_Del	6	0.11	SNU349	N	1	0	8	N
MLH1	YRASSQMEN	LARGE_INTESTINE	126	p.Y130fs	c.389_389delA	Frame_Shift_Del	5	0.11	CW2	N	4	0	5	N
MLH1	AAHVTITTK	LARGE_INTESTINE	110	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
MLH1	AHQMVCTDS	SKIN	380	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	1	0	0	N
MLH1	AKRGPTSSN	KIDNEY	460	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	ALASISHAA	LARGE_INTESTINE	103	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	3	0	0	N
MLH1	ALCSHILPP	LARGE_INTESTINE	723	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	ALKNPSEKY	LARGE_INTESTINE	165	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	5	0	0	N
MLH1	ANCIKEMIE	UPPER_AERODIGESTIVE_TRACT	29	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	0	0	0	N
MLH1	APLFDLVML	PROSTATE	580	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	Y	22	10	0	N
MLH1	ASISHAAHV	LARGE_INTESTINE	105	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	5	0	0	N
MLH1	ASYSHGKLK	BREAST	128	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	1	0	0	N
MLH1	AVSREMIEI	OVARY	223	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	Y	4	12	0	N
MLH1	AYRASYSHG	BREAST	125	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	Y	0	9	0	N
MLH1	CAYRASYSH	BREAST	124	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	0	0	0	N
MLH1	CCVNPQWAL	ENDOMETRIUM	532	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	Y	8	9	0	N
MLH1	CERFITSKL	LARGE_INTESTINE	77	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	Y	9	9	0	N
MLH1	CIAAGEVIQ	LUNG	18	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	0	0	0	N
MLH1	CIFLLFMNH	LUNG	256	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	2	0	0	N
MLH1	CIFSLFINH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	256	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	N	2	0	0	N
MLH1	CIKEMIENC	UPPER_AERODIGESTIVE_TRACT	31	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	0	0	0	N
MLH1	CSHILPPKH	LARGE_INTESTINE	725	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	CTDSREQKL	SKIN	385	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	Y	9	10	0	N
MLH1	CVPPLEGLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	646	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	0	0	0	N
MLH1	DALASISHV	ENDOMETRIUM	102	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	5	0	0	N
MLH1	DETVLNRIA	CENTRAL_NERVOUS_SYSTEM	12	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	5	0	0	N
MLH1	DETVVNCIA	LUNG	12	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	6	0	0	N
MLH1	DGRKEGLAE	URINARY_TRACT	601	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	0	0	0	N
MLH1	DIVCERFIT	LARGE_INTESTINE	74	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	1	0	0	N
MLH1	DKEGNLIGL	UPPER_AERODIGESTIVE_TRACT	631	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	Y	5	13	0	N
MLH1	DLVMLALDS	PROSTATE	584	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	0	0	0	N
MLH1	DNCVPPLEG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	644	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	0	0	0	N
MLH1	DNDVPPLEG	LARGE_INTESTINE	644	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	1	0	0	N
MLH1	DVPPLEGLP	LARGE_INTESTINE	646	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
MLH1	DYFSLEIDK	UPPER_AERODIGESTIVE_TRACT	624	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	2	0	0	N
MLH1	EALASISHA	LARGE_INTESTINE	102	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	4	0	0	N
MLH1	EDGRKEGLA	URINARY_TRACT	600	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	4	0	0	N
MLH1	EEDGRKEGL	URINARY_TRACT	599	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	6	0	0	N
MLH1	EESIMERVQ	LARGE_INTESTINE	319	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	1	0	0	N
MLH1	EHIVYKALC	LARGE_INTESTINE	717	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
MLH1	EIDKEGNLI	UPPER_AERODIGESTIVE_TRACT	629	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	4	0	0	N
MLH1	EIGREDKTL	PANCREAS	230	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	3	0	0	N
MLH1	EISPHNVDV	LUNG	297	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	2	0	0	Y
MLH1	EKYGKILEV	LARGE_INTESTINE	171	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	Y	4	13	0	N
MLH1	ELIEIGRED	PANCREAS	227	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	0	0	0	N
MLH1	EMIEIGCED	OVARY	227	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	0	0	0	N
MLH1	EMSAKRGPT	KIDNEY	457	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	EPAPLFDLV	PROSTATE	578	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	Y	12	11	0	N
MLH1	ERFITSKLQ	LARGE_INTESTINE	78	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	0	0	0	N
MLH1	ESIMERVQQ	LARGE_INTESTINE	320	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	1	0	0	N
MLH1	ESISLRKAI	PANCREAS	268	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	9	0	0	N
MLH1	ETVLNRIAA	CENTRAL_NERVOUS_SYSTEM	13	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	Y	3	12	0	N
MLH1	ETVVNCIAA	LUNG	13	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	3	0	0	N
MLH1	EVIQRPANC	UPPER_AERODIGESTIVE_TRACT	23	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	2	0	0	N
MLH1	FDLVMLALD	PROSTATE	583	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	3	0	0	N
MLH1	FGNAVSREM	OVARY	220	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	8	0	10	N
MLH1	FGVLRLSGP	BREAST	571	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	2	0	0	N
MLH1	FINHSLVES	ENDOMETRIUM	261	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	2	0	18	N
MLH1	FITSKLQSF	LARGE_INTESTINE	80	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	5	0	3	N
MLH1	FLHEESIME	LARGE_INTESTINE	316	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	2	0	4	N
MLH1	FLLFINHSL	ENDOMETRIUM	258	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	Y	19	11	20	N
MLH1	FLLFMNHRL	LUNG	258	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	Y	17	12	20	N
MLH1	FMNHRLVES	LUNG	261	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	2	0	18	N
MLH1	FRGDALASI	ENDOMETRIUM	99	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	Y	8	11	13	N
MLH1	FSLEIDKEG	UPPER_AERODIGESTIVE_TRACT	626	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	1	0	0	N
MLH1	FSLFINHRL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	258	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	Y	19	10	8	N
MLH1	FVCCVNPQW	ENDOMETRIUM	530	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	4	0	4	N
MLH1	GDALASISH	ENDOMETRIUM	101	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	0	0	0	N
MLH1	GFRGDALAS	ENDOMETRIUM	98	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	0	0	0	N
MLH1	GLPLLIDNC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	638	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	4	0	0	N
MLH1	GLPLLIDND	LARGE_INTESTINE	638	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
MLH1	GNAVSREMI	OVARY	221	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	Y	3	15	0	N
MLH1	GPAPLFDLA	BREAST	578	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	10	0	0	N
MLH1	GREDKTLAF	PANCREAS	232	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	Y	3	11	0	Y
MLH1	GRKEGLAEY	URINARY_TRACT	602	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	Y	3	10	0	N
MLH1	GTSEMSAKR	KIDNEY	454	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	5	0	0	N
MLH1	GVLRLSGPA	BREAST	572	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	2	0	0	N
MLH1	GWTEEDGRK	URINARY_TRACT	596	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	0	0	0	N
MLH1	HAAHVTITT	LARGE_INTESTINE	109	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	3	0	0	N
MLH1	HEESIMERV	LARGE_INTESTINE	318	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	6	0	0	N
MLH1	HFLHEESIM	LARGE_INTESTINE	315	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	Y	3	9	0	N
MLH1	HGKLKAPPK	BREAST	132	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	1	0	0	N
MLH1	HIVYKALCS	LARGE_INTESTINE	718	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	HNHSFVCCV	ENDOMETRIUM	526	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	Y	3	13	0	N
MLH1	HNVDVNVHP	LUNG	301	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	0	0	0	N
MLH1	HQMVCTDSR	SKIN	381	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	6	0	0	N
MLH1	HRLVESISL	PANCREAS	264	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	Y	8	9	0	N
MLH1	HSFVCCVNP	ENDOMETRIUM	528	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	0	0	0	N
MLH1	HSLVESTSL	ENDOMETRIUM	264	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	11	0	0	Y
MLH1	IDKEGNLIG	UPPER_AERODIGESTIVE_TRACT	630	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	0	0	0	N
MLH1	IDNCVPPLE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	643	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	1	0	0	N
MLH1	IDNDVPPLE	LARGE_INTESTINE	643	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	1	0	0	N
MLH1	IEIGREDKT	PANCREAS	229	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	5	0	0	N
MLH1	IFLLFINHS	ENDOMETRIUM	257	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	0	0	40	N
MLH1	IFLLFMNHR	LUNG	257	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	2	0	2	N
MLH1	IFSLFINHR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	257	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	Y	2	9	3	N
MLH1	IGREDKTLA	PANCREAS	231	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	2	0	0	N
MLH1	IMERVQQHI	LARGE_INTESTINE	322	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	Y	7	9	0	N
MLH1	INHRLVESI	PANCREAS	262	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	Y	4	13	2	N
MLH1	INHSLVEST	ENDOMETRIUM	262	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	0	0	0	N
MLH1	IQRPANCIK	UPPER_AERODIGESTIVE_TRACT	25	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	Y	3	15	0	N
MLH1	IRRLDETVL	CENTRAL_NERVOUS_SYSTEM	8	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	5	0	3	N
MLH1	ISHAAHVTI	LARGE_INTESTINE	107	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	Y	7	12	0	N
MLH1	ISLRKAIET	PANCREAS	270	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	1	0	0	N
MLH1	ISPHNVDVN	LUNG	298	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	3	0	0	N
MLH1	ISTYGFRGD	ENDOMETRIUM	94	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	0	0	0	N
MLH1	ITSKLQSFE	LARGE_INTESTINE	81	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	1	0	0	N
MLH1	IVCERFITS	LARGE_INTESTINE	75	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	0	0	3	N
MLH1	IVYKALCSH	LARGE_INTESTINE	719	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	0	0	29	N
MLH1	KALCSHILP	LARGE_INTESTINE	722	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	KALKNPSEK	LARGE_INTESTINE	164	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	4	0	0	N
MLH1	KCIFLLFMN	LUNG	255	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	0	0	0	N
MLH1	KCIFSLFIN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	255	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	N	0	0	0	N
MLH1	KEGNLIGLP	UPPER_AERODIGESTIVE_TRACT	632	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	0	0	0	N
MLH1	KGTSEMSAK	KIDNEY	453	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	0	0	0	N
MLH1	KKCIFLLFM	LUNG	254	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	Y	4	9	0	N
MLH1	KKCIFSLFI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	254	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	N	4	0	0	N
MLH1	KNPSEKYGK	LARGE_INTESTINE	167	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	2	0	0	Y
MLH1	KVYAHQMVC	SKIN	377	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	3	0	0	N
MLH1	KYGKILEVV	LARGE_INTESTINE	172	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	7	0	0	N
MLH1	LASISHAAH	LARGE_INTESTINE	104	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	LCSHILPPK	LARGE_INTESTINE	724	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	2	0	0	N
MLH1	LDETVLNRI	CENTRAL_NERVOUS_SYSTEM	11	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	4	0	0	N
MLH1	LDETVVNCI	LUNG	11	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	5	0	0	N
MLH1	LDIVCERFI	LARGE_INTESTINE	73	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	9	0	0	N
MLH1	LEIDKEGNL	UPPER_AERODIGESTIVE_TRACT	628	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	12	0	0	N
MLH1	LEISPHNVD	LUNG	296	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	2	0	0	Y
MLH1	LFDLVMLAL	PROSTATE	582	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	9	0	0	N
MLH1	LFINHSLVE	ENDOMETRIUM	260	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	0	0	16	N
MLH1	LFMNHRLVE	LUNG	260	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	0	0	24	N
MLH1	LHEESIMER	LARGE_INTESTINE	317	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	3	0	0	N
MLH1	LHNHSFVCC	ENDOMETRIUM	525	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	1	0	0	N
MLH1	LIDNCVPPL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	642	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	8	0	0	N
MLH1	LIDNDVPPL	LARGE_INTESTINE	642	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	8	0	0	N
MLH1	LIEIGREDK	PANCREAS	228	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	3	0	0	N
MLH1	LKNPSEKYG	LARGE_INTESTINE	166	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	0	0	0	N
MLH1	LLFINHSLV	ENDOMETRIUM	259	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	15	0	0	N
MLH1	LLFMNHRLV	LUNG	259	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	13	0	16	N
MLH1	LLIDNCVPP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	641	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	0	0	11	N
MLH1	LLIDNDVPP	LARGE_INTESTINE	641	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
MLH1	LNRIAAGEV	CENTRAL_NERVOUS_SYSTEM	16	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	2	0	2	N
MLH1	LPLLIDNCV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	639	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	13	0	0	N
MLH1	LPLLIDNDV	LARGE_INTESTINE	639	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	12	0	0	N
MLH1	LRLSGPAPL	BREAST	574	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	9	0	31	N
MLH1	LSGPAPLFD	BREAST	576	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	0	0	0	N
MLH1	LSLEISPHN	LUNG	294	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	1	0	0	N
MLH1	LVESISLRK	PANCREAS	266	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	5	0	2	N
MLH1	LVMLALDSP	PROSTATE	585	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	0	0	4	N
MLH1	MERVQQHIE	LARGE_INTESTINE	323	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	0	0	0	N
MLH1	MIEIGCEDK	OVARY	228	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	3	0	0	N
MLH1	MLHNHSFVC	ENDOMETRIUM	524	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	3	0	5	N
MLH1	MNHRLVEST	LUNG	262	p.I262M	c.786C>G	Missense_Mutation	1	0.11	NCIH510	N	0	0	0	N
MLH1	MSAKRGPTS	KIDNEY	458	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	MVCTDSREQ	SKIN	383	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	0	0	14	N
MLH1	NAVSREMIE	OVARY	222	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	0	0	0	N
MLH1	NCIAAGEVI	LUNG	17	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	6	0	0	N
MLH1	NCIKEMIEN	UPPER_AERODIGESTIVE_TRACT	30	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	0	0	0	N
MLH1	NCVPPLEGL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	645	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	Y	13	9	0	N
MLH1	NDVPPLEGL	LARGE_INTESTINE	645	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	Y	7	9	0	N
MLH1	NFGVLRLSG	BREAST	570	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	0	0	0	Y
MLH1	NHRLVESIS	PANCREAS	263	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	0	0	0	N
MLH1	NHSFVCCVN	ENDOMETRIUM	527	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	1	0	0	N
MLH1	NHSLVESTS	ENDOMETRIUM	263	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	1	0	0	N
MLH1	NPSEKYGKI	LARGE_INTESTINE	168	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	Y	14	9	0	Y
MLH1	PANCIKEMI	UPPER_AERODIGESTIVE_TRACT	28	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	3	0	0	N
MLH1	PAPLFDLVM	PROSTATE	579	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	0	0	0	N
MLH1	PHNVDVNVH	LUNG	300	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	0	0	0	N
MLH1	PLFDLVMLA	PROSTATE	581	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	4	0	0	N
MLH1	PLLIDNCVP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	640	p.Y646C	c.1937A>G	Missense_Mutation	1	0.11	NALM19	N	0	0	0	N
MLH1	PLLIDNDVP	LARGE_INTESTINE	640	p.Y646D	c.1936T>G	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
MLH1	PSEKYGKIL	LARGE_INTESTINE	169	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	0	0	0	Y
MLH1	QMVCTDSRE	SKIN	382	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	0	0	0	N
MLH1	QRPANCIKE	UPPER_AERODIGESTIVE_TRACT	26	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	1	0	0	N
MLH1	RASYSHGKL	BREAST	127	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	11	0	0	N
MLH1	REDKTLAFK	PANCREAS	233	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	Y	2	12	0	N
MLH1	RELIEIGRE	PANCREAS	226	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	1	0	0	N
MLH1	REMIEIGCE	OVARY	226	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	1	0	0	N
MLH1	RFITSKLQS	LARGE_INTESTINE	79	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	0	0	0	N
MLH1	RGDALASIS	ENDOMETRIUM	100	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	0	0	0	N
MLH1	RKEGLAEYI	URINARY_TRACT	603	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	Y	1	17	0	N
MLH1	RLDETVLNR	CENTRAL_NERVOUS_SYSTEM	10	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	Y	8	10	0	N
MLH1	RLDETVVNC	LUNG	10	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	Y	2	11	0	N
MLH1	RLSGPAPLF	BREAST	575	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	10	0	0	N
MLH1	RLVESISLR	PANCREAS	265	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	Y	7	9	0	N
MLH1	RPANCIKEM	UPPER_AERODIGESTIVE_TRACT	27	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	Y	11	9	0	N
MLH1	RRLDETVLN	CENTRAL_NERVOUS_SYSTEM	9	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	2	0	0	N
MLH1	SAKRGPTSS	KIDNEY	459	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	SEKYGKILE	LARGE_INTESTINE	170	p.E172K	c.514G>A	Missense_Mutation	1	0.11	LS411N	N	0	0	0	N
MLH1	SEMSAKRGP	KIDNEY	456	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	SFVCCVNPQ	ENDOMETRIUM	529	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	0	0	0	N
MLH1	SGPAPLFDL	BREAST	577	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	Y	12	9	0	N
MLH1	SGWTEEDGR	URINARY_TRACT	595	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	1	0	0	N
MLH1	SHAAHVTIT	LARGE_INTESTINE	108	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	1	0	0	N
MLH1	SHGKLKAPP	BREAST	131	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	0	0	0	N
MLH1	SIMERVQQH	LARGE_INTESTINE	321	p.L323M	c.967C>A	Missense_Mutation	1	0.11	RKO	N	0	0	0	N
MLH1	SISHAAHVT	LARGE_INTESTINE	106	p.V110A	c.329T>C	Missense_Mutation	1	0.11	SNU1040	N	0	0	0	N
MLH1	SISLRKAIE	PANCREAS	269	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	0	0	0	N
MLH1	SLEIDKEGN	UPPER_AERODIGESTIVE_TRACT	627	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	1	0	0	N
MLH1	SLEISPHNV	LUNG	295	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	Y	3	12	0	N
MLH1	SLFINHRLV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	259	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	Y	7	10	0	N
MLH1	SLVESTSLR	ENDOMETRIUM	265	p.R265S	c.793C>A	Missense_Mutation	1	0.11	HEC151	N	5	0	0	N
MLH1	SPHNVDVNV	LUNG	299	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	Y	12	10	0	N
MLH1	SRELIEIGR	PANCREAS	225	p.C233R	c.697T>C	Missense_Mutation	1	0.11	SNU324	N	4	0	0	N
MLH1	SREMIEIGC	OVARY	225	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	2	0	0	N
MLH1	STYGFRGDA	ENDOMETRIUM	95	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	1	0	0	N
MLH1	SVKKCIFSL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	252	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	Y	6	10	0	N
MLH1	SYSHGKLKA	BREAST	129	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	2	0	0	N
MLH1	TEEDGRKEG	URINARY_TRACT	598	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	0	0	0	N
MLH1	TKGTSEMSA	KIDNEY	452	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	TSEMSAKRG	KIDNEY	455	p.E460A	c.1379A>C	Missense_Mutation	1	0.11	786O	N	1	0	0	N
MLH1	TVLNRIAAG	CENTRAL_NERVOUS_SYSTEM	14	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	0	0	0	N
MLH1	TVVNCIAAG	LUNG	14	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	0	0	0	N
MLH1	TYGFRGDAL	ENDOMETRIUM	96	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	Y	6	10	0	N
MLH1	VCCVNPQWA	ENDOMETRIUM	531	p.G532C	c.1594G>T	Missense_Mutation	1	0.11	HEC251	N	3	0	0	N
MLH1	VCERFITSK	LARGE_INTESTINE	76	p.T81I	c.242C>T	Missense_Mutation	1	0.11	CL34	N	3	0	0	N
MLH1	VCTDSREQK	SKIN	384	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	1	0	6	N
MLH1	VESISLRKA	PANCREAS	267	p.T270I	c.809C>T	Missense_Mutation	1	0.11	MIAPACA2	N	6	0	0	N
MLH1	VIQRPANCI	UPPER_AERODIGESTIVE_TRACT	24	p.A31C	c.91_92GC>TG	Missense_Mutation	1	0.11	HS840T	N	5	0	3	N
MLH1	VKKCIFSLF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	253	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	N	4	0	0	N
MLH1	VLNRIAAGE	CENTRAL_NERVOUS_SYSTEM	15	p.V16L	c.46G>C	Missense_Mutation	1	0.11	YKG1	N	0	0	6	N
MLH1	VLRLSGPAP	BREAST	573	p.E578G	c.1733A>G	Missense_Mutation	1	0.11	BT20	N	0	0	2	N
MLH1	VMLALDSPE	PROSTATE	586	p.A586V	c.1757C>T	Missense_Mutation	1	0.11	DU145	N	0	0	1	N
MLH1	VNCIAAGEV	LUNG	16	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	1	0	0	N
MLH1	VSREMIEIG	OVARY	224	p.L228M	c.682C>A	Missense_Mutation	1	0.11	HEYA8	N	0	0	0	N
MLH1	VVNCIAAGE	LUNG	15	p.R18C	c.52C>T	Missense_Mutation	1	0.11	NCIH1792	N	0	0	8	N
MLH1	VYAHQMVCT	SKIN	378	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	1	0	0	N
MLH1	VYKALCSHI	LARGE_INTESTINE	720	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	Y	5	10	2	N
MLH1	WTEEDGRKE	URINARY_TRACT	597	p.P603R	c.1808C>G	Missense_Mutation	1	0.11	HT1376	N	1	0	0	N
MLH1	YAHQMVCTD	SKIN	379	p.R385C	c.1153C>T	Missense_Mutation	1	0.11	MEWO	N	2	0	1	N
MLH1	YFSLEIDKE	UPPER_AERODIGESTIVE_TRACT	625	p.E632K	c.1894G>A	Missense_Mutation	1	0.11	HSC4	N	1	0	1	N
MLH1	YGFRGDALA	ENDOMETRIUM	97	p.E102D	c.306G>T	Missense_Mutation	1	0.11	HEC59	N	8	0	1	N
MLH1	YKALCSHIL	LARGE_INTESTINE	721	p.R725C	c.2173C>T	Missense_Mutation	1	0.11	SNU1040	N	5	0	12	N
MLH1	YLSLEISPH	LUNG	293	p.Q301H	c.903G>T	Missense_Mutation	1	0.11	NCIH1573	N	1	0	15	N
MLH1	YRASYSHGK	BREAST	126	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	4	0	11	N
MLH1	YSHGKLKAP	BREAST	130	p.D132H	c.394G>C	Missense_Mutation	1	0.11	HCC1428	N	1	0	0	N
MLH1	YSVKKCIFS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	251	p.L259S	c.776T>C	Missense_Mutation	1	0.11	KCL22	N	2	0	5	N
MLH1	AHVTITMKT	LARGE_INTESTINE	111	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	1	0	0	N
MLH1	AHVTITMKT	LARGE_INTESTINE	111	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	1	0	0	N
MLH1	HVAHVTITM	LARGE_INTESTINE	109	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	Y	6	10	0	N
MLH1	HVAHVTITM	LARGE_INTESTINE	109	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	Y	6	10	0	N
MLH1	HVTITMKTA	LARGE_INTESTINE	112	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	2	0	0	N
MLH1	HVTITMKTA	LARGE_INTESTINE	112	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	2	0	0	N
MLH1	ITMKTADGK	LARGE_INTESTINE	115	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	4	0	0	N
MLH1	ITMKTADGK	LARGE_INTESTINE	115	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	4	0	0	N
MLH1	MKTADGKCA	LARGE_INTESTINE	117	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	2	0	0	N
MLH1	MKTADGKCA	LARGE_INTESTINE	117	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	2	0	0	N
MLH1	TITMKTADG	LARGE_INTESTINE	114	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	0	0	0	N
MLH1	TITMKTADG	LARGE_INTESTINE	114	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	0	0	0	N
MLH1	TMKTADGKC	LARGE_INTESTINE	116	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	0	0	0	N
MLH1	TMKTADGKC	LARGE_INTESTINE	116	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	0	0	0	N
MLH1	VAHVTITMK	LARGE_INTESTINE	110	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	1	0	0	N
MLH1	VAHVTITMK	LARGE_INTESTINE	110	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	1	0	0	N
MLH1	VTITMKTAD	LARGE_INTESTINE	113	p.T117M	c.350C>T	Missense_Mutation	1	0.22	CCK81	N	0	0	0	N
MLH1	VTITMKTAD	LARGE_INTESTINE	113	p.T117M	c.350C>T	Missense_Mutation	1	0.22	LS180	N	0	0	0	N
MLH1	ASTVDNICS	ENDOMETRIUM	210	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	0	0	0	N
MLH1	ASTVDNICS	ENDOMETRIUM	210	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	0	0	0	N
MLH1	ASTVDNICS	LUNG	210	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	0	0	0	N
MLH1	CSIFGNAVS	ENDOMETRIUM	217	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	0	0	0	N
MLH1	CSIFGNAVS	ENDOMETRIUM	217	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	0	0	0	N
MLH1	CSIFGNAVS	LUNG	217	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	0	0	0	N
MLH1	DNICSIFGN	ENDOMETRIUM	214	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	0	0	0	N
MLH1	DNICSIFGN	ENDOMETRIUM	214	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	0	0	0	N
MLH1	DNICSIFGN	LUNG	214	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	0	0	0	N
MLH1	ICSIFGNAV	ENDOMETRIUM	216	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	Y	2	9	1	N
MLH1	ICSIFGNAV	ENDOMETRIUM	216	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	Y	2	9	1	N
MLH1	ICSIFGNAV	LUNG	216	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	Y	2	9	1	N
MLH1	NASTVDNIC	ENDOMETRIUM	209	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	3	0	0	N
MLH1	NASTVDNIC	ENDOMETRIUM	209	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	3	0	0	N
MLH1	NASTVDNIC	LUNG	209	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	3	0	0	N
MLH1	NICSIFGNA	ENDOMETRIUM	215	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	0	0	0	N
MLH1	NICSIFGNA	ENDOMETRIUM	215	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	0	0	0	N
MLH1	NICSIFGNA	LUNG	215	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	0	0	0	N
MLH1	STVDNICSI	ENDOMETRIUM	211	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	Y	6	13	0	N
MLH1	STVDNICSI	ENDOMETRIUM	211	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	Y	6	13	0	N
MLH1	STVDNICSI	LUNG	211	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	Y	6	13	0	N
MLH1	TVDNICSIF	ENDOMETRIUM	212	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	Y	3	9	0	N
MLH1	TVDNICSIF	ENDOMETRIUM	212	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	Y	3	9	0	N
MLH1	TVDNICSIF	LUNG	212	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	Y	3	9	0	N
MLH1	VDNICSIFG	ENDOMETRIUM	213	p.R217C	c.649C>T	Missense_Mutation	1	0.33	HEC265	N	1	0	0	N
MLH1	VDNICSIFG	ENDOMETRIUM	213	p.R217C	c.649C>T	Missense_Mutation	1	0.33	JHUEM1	N	1	0	0	N
MLH1	VDNICSIFG	LUNG	213	p.R217C	c.649C>T	Missense_Mutation	1	0.33	RERFLCMS	N	1	0	0	N