Cell Line Summary Result page in PCMdb

Search:
PCMDB ID Origin Name Genes Cancer Type Control Mehtylation
Category		 Method Reference
PCM059083Tissue Sample30 xenograftsCCND3AdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM059110Tissue Sample30 xenograftsFRKAdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM059149Tissue Sample30 xenograftsNOTCH4AdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM059155Tissue Sample30 xenograftsPPARDAdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM059173Tissue Sample30 xenograftsSLC22A3AdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM059175Tissue Sample30 xenograftsSPDEFAdenoHPNE and HPDE cell lines, 7 normal xenograft tissuesLowIMA19497796
PCM0286Cell LineCAPAN1Sod2S_notLowBisulphite Sequencin17895890
PCM012052Cell LineASPC1AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012053Cell LineMIAPACA2AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012054Cell LineCAPAN2AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012055Cell LineA321AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012056Cell LineA385AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012057Cell LinePANC2AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012058Cell LinePANC3014AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012059Cell LinePANC215AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012060Cell LinePANC25AMD1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012340Cell LineASPC1PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012341Cell LineMIAPACA2PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012342Cell LineCAPAN2PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012343Cell LineA321PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012344Cell LineA385PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012345Cell LinePANC2PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012346Cell LinePANC3014PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012347Cell LinePANC215PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012348Cell LinePANC25PRSS16Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012565Cell LineASPC1MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012566Cell LineMIAPACA2MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012567Cell LineCAPAN2MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012568Cell LineA321MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012569Cell LineA385MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012570Cell LinePANC2MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012571Cell LinePANC3014MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012572Cell LinePANC215MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012573Cell LinePANC25MAP3K7Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012709Cell LineASPC1NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012710Cell LineMIAPACA2NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012711Cell LineCAPAN2NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012712Cell LineA321NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012713Cell LineA385NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012714Cell LinePANC2NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012715Cell LinePANC3014NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012716Cell LinePANC215NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012717Cell LinePANC25NT5EAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012763Cell LineASPC1SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012764Cell LineMIAPACA2SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012765Cell LineCAPAN2SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012766Cell LineA321SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012767Cell LineA385SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012768Cell LinePANC2SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012769Cell LinePANC3014SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012770Cell LinePANC215SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM012771Cell LinePANC25SYNJ2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013015Cell LineASPC1MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013016Cell LineMIAPACA2MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013017Cell LineCAPAN2MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013018Cell LineA321MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013019Cell LineA385MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013020Cell LinePANC2MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013021Cell LinePANC3014MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013022Cell LinePANC215MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013023Cell LinePANC25MYBAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013123Cell LineASPC1TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013124Cell LineMIAPACA2TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013125Cell LineCAPAN2TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013126Cell LineA321TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013127Cell LineA385TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013128Cell LinePANC2TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013129Cell LinePANC3014TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013130Cell LinePANC215TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013131Cell LinePANC25TCF21Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013861Cell LineASPC1KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013862Cell LineMIAPACA2KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013863Cell LineCAPAN2KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013864Cell LineA321KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013865Cell LineA385KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013866Cell LinePANC2KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013867Cell LinePANC3014KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013868Cell LinePANC215KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM013869Cell LinePANC25KHDRBS2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014230Cell LineASPC1SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014231Cell LineMIAPACA2SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014232Cell LineCAPAN2SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014233Cell LineA321SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014234Cell LineA385SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014235Cell LinePANC2SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014236Cell LinePANC3014SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014237Cell LinePANC215SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014238Cell LinePANC25SOBPAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014428Cell LineASPC1ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014429Cell LineMIAPACA2ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014430Cell LineCAPAN2ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014431Cell LineA321ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014432Cell LineA385ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014433Cell LinePANC2ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014434Cell LinePANC3014ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014435Cell LinePANC215ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014436Cell LinePANC25ATG5Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014761Cell LineASPC1FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014762Cell LineMIAPACA2FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014763Cell LineCAPAN2FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014764Cell LineA321FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014765Cell LineA385FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014766Cell LinePANC2FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014767Cell LinePANC3014FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014768Cell LinePANC215FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014769Cell LinePANC25FAM184AAdenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014788Cell LineASPC1FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014789Cell LineMIAPACA2FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014790Cell LineCAPAN2FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014791Cell LineA321FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014792Cell LineA385FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014793Cell LinePANC2FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014794Cell LinePANC3014FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014795Cell LinePANC215FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014796Cell LinePANC25FAM8A1Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014932Cell LineASPC1LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014933Cell LineMIAPACA2LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014934Cell LineCAPAN2LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014935Cell LineA321LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014936Cell LineA385LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014937Cell LinePANC2LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014938Cell LinePANC3014LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014939Cell LinePANC215LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014940Cell LinePANC25LEMD2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014986Cell LineASPC1LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014987Cell LineMIAPACA2LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014988Cell LineCAPAN2LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014989Cell LineA321LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014990Cell LineA385LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014991Cell LinePANC2LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014992Cell LinePANC3014LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014993Cell LinePANC215LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM014994Cell LinePANC25LRFN2Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015004Cell LineASPC1LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015005Cell LineMIAPACA2LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015006Cell LineCAPAN2LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015007Cell LineA321LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015008Cell LineA385LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015009Cell LinePANC2LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015010Cell LinePANC3014LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015011Cell LinePANC215LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144
PCM015012Cell LinePANC25LYRM4Adenopooled laser-captured microdissected normal pancreatic ductal tissues,normal pancreatic tissue,nonneLowMCAM21610144


   Team Contact Us Raghava CSIR-IMTECH CSIR