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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for 1,12 are 2
Results from 0 - 25
| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM3379 |
GUCAUCACACUGAAUACCAAU
AUUGGUAUUCAGUGUGAUGACAC |
2-O-Methyl
2-O-Methyl |
1,12
2,3,6,8,9,13,15,18 |
Sugar
Sugar |
IC-50 = 1.5 nM for target mRNA | 16343994 |
| SM4024 |
AGCUCUUUGUCACCUCUCUTT
AGAGAGGUGACAAAGAGCUTT |
2-O-Methyl
2-O-Methyl |
1,12
1,3,5,7,9,11,13,15,17,19 |
Sugar
Sugar |
19 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |