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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand



1. 0
   
   
2. 1,3-Benzenedimethanol
   
   
3. 1-Aminohexane
   
   
4. 2,3-Di-Chlorobenzene
   
   
5. 2,4-bridged nucleic acid* DeoxyThymidine
   
   
6. 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
   
   
7. 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
   
   
8. 2,4-Difluorobenzene
   
   
9. 2,4-Difluorotoluene
   
   
10. 2,4-Locked nucleic acid
    
    
11. 2-Aminoethoxymethyl
    
    
12. 2-Aminoethoxymethyl* 2-Deoxy
    
    
13. 2-Aminoethyl
    
    
14. 2-Aminopropoxymethyl* 2-Deoxy
    
    
15. 2-Aminopropyl
    
    
16. 2-Deoxy
    
    
17. 2-Deoxy* 2-Fluoro* 2-Methoxy
    
    
18. 2-Deoxy* 2-Methoxy
    
    
19. 2-Deoxy-2-Fluoro
    
    
20. 2-Deoxy-2-Fluoro* 2-O-Methyl
    
    
21. 2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    
    
22. 2-Deoxy-2-Fluoroarabinonucleic acid
    
    
23. 2-Deoxy-2-fluorouridine
    
    
24. 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    
    
25. 2-Deoxyribonucleotide
    
    
26. 2-Deoxyribonucleotide*  [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol
    
    
27. 2-Deoxyribonucleotide* Inverted abasic
    
    
28. 2-Deoxyribonucleotide* Inverted thymidine
    
    
29. 2-Deoxythymidine
    
    
30. 2-Deoxythymidine (Mutation)
    
    
31. 2-Deoxythymidine * 3-Amino
    
    
32. 2-Deoxythymidine* 5-Amino * 3-Amino
    
    
33. 2-Deoxythymidine* Biotin
    
    
34. 2-Deoxythymidine* Puromycin
    
    
35. 2-Fluoro
    
    
36. 2-Fluoro* 2-Deoxy
    
    
37. 2-Fluoro* 2-Deoxy* 2-Methoxy
    
    
38. 2-Fluoro* 2-Hydroxy* 2-Methoxy
    
    
39. 2-Fluoro* 2-Methoxy
    
    
40. 2-Fluoro* 2-Methoxy* 2-Hydroxy
    
    
41. 2-Fluoro* 2-O-Methyl
    
    
42. 2-Fluoro* Cholesterol
    
    
43. 2-Fluoro* Inverted DeoxyThymidine
    
    
44. 2-Fluoro* Phosphorothioate
    
    
45. 2-Fluororibose* 3-O-methylribose* Phosphorothioate
    
    
46. 2-Fluororibose* Phosphorothioate
    
    
47. 2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate
    
    
48. 2-Fluororibose* Xylo-O-methylribose* Phosphorothioate
    
    
49. 2-Hydroxy* 2-Fluoro* 2-Methoxy
    
    
50. 2-Hydroxy* 2-Methoxy
    
    
51. 2-Methoxy* 2-Deoxy
    
    
52. 2-Methoxy* 2-Fluoro
    
    
53. 2-Methoxy* 2-Fluoro* 2-Hydroxy
    
    
54. 2-Methoxy* 2-Hydroxy
    
    
55. 2-Methoxyribose* DeoxyThymidine
    
    
56. 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    
    
57. 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    
    
58. 2-O-Aminoethyl-ribose
    
    
59. 2-O-Benzyl
    
    
60. 2-O-Guanidinopropyl
    
    
61. 2-O-Lysylaminohexyl
    
    
62. 2-O-methoxyethylribose
    
    
63. 2-O-methoxyethylribose* Phosphorothioate
    
    
64. 2-O-Methyl
    
    
65. 2-O-Methyl ribose
    
    
66. 2-O-Methyl* 2-Aminoethyl
    
    
67. 2-O-Methyl* 2-Cyanoethyl
    
    
68. 2-O-Methyl* 2-Fluoro
    
    
69. 2-O-Methyl* 2-Fluoro* 5-Phosphate
    
    
70. 2-O-Methyl* 2-Fluoro* Cholesterol
    
    
71. 2-O-Methyl* 2-O-Benzyl
    
    
72. 2-O-Methyl* Cholesterol
    
    
73. 2-O-Methyl* Cy3
    
    
74. 2-O-Methyl* Phosphate
    
    
75. 2-O-Methyl* Phosphodiester
    
    
76. 2-O-Methyl* Phosphorothioate
    
    
77. 2-O-Methyl-4-Thioribose* 2-Deoxy
    
    
78. 2-O-Methylribose
    
    
79. 2-Thiouridine
    
    
80. 3-Amino
    
    
81. 4-C- Aminomethyl-2-O-Methylribose
    
    
82. 4-C-Hydroxymethyl Deoxyribonucleic acid
    
    
83. 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid
    
    
84. 4-Methylbenzimidazole
    
    
85. 4-Thioribose
    
    
86. 4-Thioribose* 2-O-Methyl
    
    
87. 4-Thioribose* Phosphorothioate
    
    
88. 5-Amino
    
    
89. 5-Amino* 2-Deoxythymidine
    
    
90. 5-Bromo-Uridine
    
    
91. 5-Fluoro-2-Deoxyuridine
    
    
92. 5-Fluoro-2-Deoxyuridine* Deoxyadenine
    
    
93. 5-Fluoro-2-Deoxyuridine* Mismatch
    
    
94. 5-hydroxy ribose* 2-Deoxy
    
    
95. 5-hydroxy ribose* 2-Methoxy
    
    
96. 5-Iodo-Uridine
    
    
97. 5-phosphate ribose* 2-Deoxy
    
    
98. 5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    
    
99. 5-phosphate ribose* 2-Deoxy* 2-Methoxy
    
    
100. 5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
     
     
101. 5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
     
     
102. 5-phosphate ribose* 2-Fluoro* 2-Methoxy
     
     
103. 5-phosphate ribose* 2-Fluoro* 2-Methoxy* 2-Hydroxy
     
     
104. 5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
     
     
105. 5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methyl
     
     
106. 5-phosphate ribose* 2-Hydroxy* 2-Methoxy
     
     
107. 5-phosphate ribose* 2-Hydroxy* 2-Methoxy* 2-Fluoro
     
     
108. 5-phosphate ribose* 2-Methoxy
     
     
109. 5-phosphate ribose* 2-Methoxy* 2-Fluoro
     
     
110. 5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
     
     
111. 5-phosphate ribose* 2-Methoxy* 2-Hydroxy
     
     
112. 5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
     
     
113. 5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
     
     
114. 5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
     
     
115. 5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
     
     
116. 5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
     
     
117. 5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy* 2-Hydroxy
     
     
118. 5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
     
     
119. 5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
     
     
120. 5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro
     
     
121. 5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro* 2-Hydroxy
     
     
122. 5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
     
     
123. 5-Thio
     
     
124. Alfa-L-Locked nucleic acid
     
     
125. Altritol nucleic acid
     
     
126. Aminoisonucleotide-Adenine* 2-Deoxythymidine
     
     
127. Aminoisonucleotide-thymidine* Aminoisonucleotide-adenine* 2-Deoxythymidine
     
     
128. Anthracene
     
     
129. Assymetric siRNA (3-End Overhang)
     
     
130. Boranophosphate
     
     
131. Boron cluster
     
     
132. Cyclohexenyl nucleic acid* 2-Deoxythymidine
     
     
133. D-Isonucleoside adenosine* 2-Deoxythymidine
     
     
134. D-Isonucleoside uracil* 2-Deoxythymidine
     
     
135. Deoxyadenine
     
     
136. Deoxyadenine* Mismatch
     
     
137. DeoxyThymidine
     
     
138. Deoxyuridine
     
     
139. Diaminopurine
     
     
140. Difluorotoluyl nucleotide
     
     
141. Dihydrouridine
     
     
142. Dimethoxy-Nitrophenyl Ethyl group
     
     
143. Fluorobenzene
     
     
144. Galactose
     
     
145. Glucosamine analogue
     
     
146. Hexitol nucleic acid
     
     
147. Hexitol nucleic acid* 2-Deoxy
     
     
148. Hypoxanthine
     
     
149. Hypoxanthine* 2-O-Benzyl
     
     
150. L-Isonucleoside adenosine* 2-Deoxythymidine
     
     
151. L-isonucleoside thymidine* 2-Deoxythymidine
     
     
152. L-Isonucleoside uracil* 2-Deoxythymidine
     
     
153. Locked nucleic acid
     
     
154. Locked nucleic acid* 2-O-Methylribose
     
     
155. Locked nucleic acid* Methylcytosine
     
     
156. Locked nucleic acid* Phosphodiester
     
     
157. Locked nucleic acid* Phosphodiester* 2-O-Methyl
     
     
158. Locked nucleic acid* Phosphorothioate
     
     
159. Locked nucleic acid* Thymidine
     
     
160. Methyl
     
     
161. Methylcytosine
     
     
162. Methylcytosine* Propynyluridine
     
     
163. Methyleneamide
     
     
164. Methyluridine
     
     
165. Morpholinouridine
     
     
166. Mutation* 5-O-Methyl
     
     
167. N-3 Methyluridine
     
     
168. N4-Ethyl-N4 2-Deoxy-5-Methylcytidine
     
     
169. N6-Ethyl-N6 2-Deoxyadenosine
     
     
170. Naphthalene modification
     
     
171. O-Methyl
     
     
172. Palmitic Acid
     
     
173. Peptide nucleic acids
     
     
174. Phosphate
     
     
175. Phosphate* Serinol nucleic acid
     
     
176. Phosphodiester
     
     
177. Phosphorothioate
     
     
178. Phosphorothioate* 2-Deoxy-2-fluororibose
     
     
179. Phosphorothioate* 2-O-(2-methoxyethyl)ribose
     
     
180. Phosphorothioate* 2-O-Fluoro
     
     
181. Phosphorothioate* 2-O-methoxyethylribose
     
     
182. Phosphorothioate* 2-O-Methyl
     
     
183. Phosphorothioate* 2-O-Methylribose
     
     
184. Phosphorothioate* Deoxy* 2-Fluoro* 2-O-Methyl
     
     
185. Phosphorothioate* Dimethoxy-Nitrophenyl Ethyl group
     
     
186. Phosphorothioate* Locked nucleic acid
     
     
187. Phosphorothioate* Phosphodiester
     
     
188. Phosphorothioate* Phosphodiester* 2-O-Methyl
     
     
189. Propynyluridine
     
     
190. Pseudouridine
     
     
191. Pyrene modification
     
     
192. Serinol nucleic acid
     
     
193. Thymidine
     
     
194. Thymidine analogue
     
     
195. Triazole-linked nucleic acid
     
     
196. Tricyclodeoxyribonucleic acid
     
     
197. Trifluoromethylbenzene
     
     
198. Unlocked nucleic acid
     
     
199. Unlocked nucleic acid * Locked nucleic acid
     
     
200. Unlocked nucleic acid* Locked nucleic acid
     


• By modification position in antisense strand


• Reference