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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxythymidine are 142
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2332
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    82 percent target mRNA inhibition
    17539595
    SM2333
    CUGGUAAAGCAUUCAGUATT
    AUACUGAAUGCUUUACCAGTT
    Aminoisonucleotide-thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    19* 20,21
    20,21
    Base
    Sugar
    85 percent target mRNA inhibition
    17539595
    SM2334
    CTGGUAAAGCAUUCAGUATTT
    AUACUGAAUGCUUUACCAGTT
    Aminoisonucleotide-thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    2* 20,21
    20,21
    Base
    Sugar
    83 percent target mRNA inhibition
    17539595
    SM2335
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    Aminoisonucleotide-Adenine* 2-Deoxythymidine
    2-Deoxythymidine
    8* 20,21
    20,21
    Base
    Sugar
    78 percent target mRNA inhibition
    17539595
    SM2336
    CTGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    Aminoisonucleotide-thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    2,20* 21
    20,21
    Base
    Sugar
    62 percent target mRNA inhibition
    17539595
    SM2337
    CTGGUAAAGCAUUCAGUATT
    AUACUGAAUGCUUUACCAGTT
    Aminoisonucleotide-thymidine* Aminoisonucleotide-Adenine* 2-Deoxythymidine
    2-Deoxythymidine
    2,20* 6,15* 21
    20,21
    Base
    Sugar
    39 percent target mRNA inhibition
    17539595
    SM2391
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    2-Deoxythymidine
    0
    20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    23682837
    SM2392
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    D-Isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    8* 20,21
    20,21
    Base
    Sugar
    89 percent target mRNA inhibition
    23682837
    SM2393
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    L-Isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    8* 20,21
    20,21
    Base
    Sugar
    22 percent target mRNA inhibition
    23682837
    SM2394
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    D-Isonucleoside uracil* 2-Deoxythymidine
    2-Deoxythymidine
    9* 20,21
    20,21
    Base
    Sugar
    31 percent target mRNA inhibition
    23682837
    SM2395
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    L-Isonucleoside uracil* 2-Deoxythymidine
    2-Deoxythymidine
    9* 20,21
    20,21
    Base
    Sugar
    10 percent target mRNA inhibition
    23682837
    SM2396
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    D-Isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    15* 20,21
    20,21
    Base
    Sugar
    0 percent target mRNA inhibition
    23682837
    SM2397
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    L-Isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    15* 20,21
    20,21
    Base
    Sugar
    0 percent target mRNA inhibition
    23682837
    SM2398
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    D-Isonucleoside-uracil* 2-Deoxythymidine
    2-Deoxythymidine
    19* 20,21
    20,21
    Base
    Sugar
    0 percent target mRNA inhibition
    23682837
    SM2399
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    L-Isonucleoside uracil* 2-Deoxythymidine
    2-Deoxythymidine
    19* 20,21
    20,21
    Base
    Sugar
    0 percent target mRNA inhibition
    23682837
    SM2493
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2499
    TTCGUUAGCAGAAACAAAAGGAG
    TTCUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2500
    TTCGUGAGCACAAAGAAAAUGAG
    TTCUCAUUUUCUUUGUGCUCACG
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine
    1,2 (6,11,15,20)
    1,2
    Sugar (Base)
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2501
    UGGAAUGAACCACUGGAAUUUTT
    AAAUUCCAGUGGUUCAUUCCATT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2502
    UGGUAUCAAGCUCAGGAAUAUTT
    AUAUUCCUGAGCUUGAUACCATT
    2-Deoxythymidine (Mutation)
    2-Deoxythymidine
    22,23 (4,7,10,12,14,20)
    22,23
    Sugar (Base)
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2504
    TTUGGAAUGAACCACUGGAAUUU
    TTAAAUUCCAGUGGUUCAUUCCA
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2516
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine
    22,23 * 1* 23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM4219
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    94 percent target mRNA inhibition
    22895883
    SM4220
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    92 percent target mRNA inhibition
    22895883
    SM4221
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    19 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    95 percent target mRNA inhibition
    22895883