| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0005 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl |
1,2 * 22
2 |
Sugar
Sugar |
81.4 percent target mRNA inhibition | 19282453 |
| SM0051 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl* 2-Aminoethyl |
1,2 * 22
1 * 21 |
Sugar
Sugar |
82 percent target mRNA inhibition | 19282453 |
| SM0096 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl* 2-Cyanoethyl |
1,2 * 22
1 * 18 |
Sugar
Sugar |
54.8 percent target mRNA inhibition | 19282453 |
| SM0141 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
1,2 * 22
1,2 |
Sugar
Sugar |
57.1 percent target mRNA inhibition | 19282453 |
| SM0186 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
1,2 * 22
20,21 |
Sugar
Sugar |
88.5 percent target mRNA inhibition | 19282453 |
| SM0231 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
1,2 * 22
5,8,11,14,17,20 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0276 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
1,2 * 22
3,6,14,18,20,21 |
Sugar
Sugar |
80.3 percent target mRNA inhibition | 19282453 |
| SM0321 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2 * 22
18,19,20 * 21 |
Sugar
Sugar |
85.4 percent target mRNA inhibition | 19282453 |
| SM0366 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2 * 22
2,18,19,20 * 21 |
Sugar
Sugar |
75.4 percent target mRNA inhibition | 19282453 |
| SM0411 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2 * 22
3,18,19,20 * 21 |
Sugar
Sugar |
77.7 percent target mRNA inhibition | 19282453 |
| SM0456 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2 * 22
2,9,18,19,20 * 21 |
Sugar
Sugar |
33.8 percent target mRNA inhibition | 19282453 |
| SM0501 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminoethoxymethyl* 2-Deoxy |
1,2 * 22
18,19 * 21 |
Sugar
Sugar |
54.8 percent target mRNA inhibition | 19282453 |
| SM0546 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
1,2 * 22
18,19 * 21 |
Sugar
Sugar |
47.5 percent target mRNA inhibition | 19282453 |
| SM0591 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Fluoro* 2-O-Methyl |
1,2 * 22
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 |
Sugar
Sugar |
81.8 percent target mRNA inhibition | 19282453 |
| SM0636 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
1,2 * 22
3,18 |
Sugar
Sugar |
59.1 percent target mRNA inhibition | 19282453 |
| SM0681 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
1,2 * 22
4,18 |
Sugar
Sugar |
26.9 percent target mRNA inhibition | 19282453 |
| SM0726 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
1,2 * 22
3,4,18 |
Sugar
Sugar |
87.9 percent target mRNA inhibition | 19282453 |
| SM0771 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
1,2 * 22
3,18 |
Sugar
Sugar |
77.4 percent target mRNA inhibition | 19282453 |
| SM0816 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
1,2 * 22
4,18 |
Sugar
Sugar |
80.8 percent target mRNA inhibition | 19282453 |
| SM0861 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
1,2 * 22
3,4,18 |
Sugar
Sugar |
89.1 percent target mRNA inhibition | 19282453 |
| SM0906 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
1,2 * 22
3,18 |
Sugar
Sugar |
75.7 percent target mRNA inhibition | 19282453 |
| SM0951 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
1,2 * 22
4,18 |
Sugar
Sugar |
81 percent target mRNA inhibition | 19282453 |
| SM0996 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
1,2 * 22
3,4,18 |
Sugar
Sugar |
73.6 percent target mRNA inhibition | 19282453 |
| SM1041 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-Aminoethyl |
1,2 * 22
20,21 |
Sugar
Sugar |
90.4 percent target mRNA inhibition | 19282453 |
| SM1086 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-Aminopropyl |
1,2 * 22
1 |
Sugar
Sugar |
49.2 percent target mRNA inhibition | 19282453 |