Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 10 are 17
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2778
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2,4-Difluorotoluene-2-Deoxyribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2782
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2,4-Difluorotoluene
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2786
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    5-Nitroindole-2-Deoxyribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2790
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    5-Nitroindole-2-Deoxyribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2794
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxynebularine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2798
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Nebularine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2802
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy-2-Aminopurine-2-Deoxyribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2806
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Aminopurineribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2810
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxyinosine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2814
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Inosine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2818
    GUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAACTT
    Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol)
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2830
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2,4-Difluorotoluene
    0
    10
    0
    Base
    0
    IC-50 = 0.056 nM for target mRNA
    20610434
    SM2845
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    10
    0
    Base
    0
    IC-50 = 0.04 nM for target mRNA
    20610434
    SM3384
    TTAUCUCCAUGCACGACUCCG
    UAGAGGUACGUGCUGAGGCTT
    2-O-Lysylaminohexyl
    2-O-Lysylaminohexyl
    10
    11
    Sugar
    Sugar
    27 percent target mRNA inhibition
    17979170
    SM3769
    ACGGCUCGCUACCCUCGACTT
    GUCGAGGGUAGCGAGCCGUTT
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    10
    9
    Sugar
    Sugar
    78 percent target mRNA inhibition
    US20120088815A1, EP2415869A1
    SM3774
    AGAGGACCUAGAAGGCGGCTT
    GCCGCCUUCUAGGUCCUCUTT
    2-O-Methyl
    0
    10
    0
    Sugar
    0
    92 percent target mRNA inhibition
    US20120088815A1, EP2415869A1
    SM3885
    GGGAGGUCUUAGAAAACACTT
    GUGUUUUCUAAGACCUCCCTT
    2-O-Methyl
    2-O-Methyl
    10
    9
    Sugar
    Sugar
    84 percent target mRNA inhibition
    US20120088815A1, EP2415869A1