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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 14 * 15 * 20,21 are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4380
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    14 * 15 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    67 percent target mRNA inhibition
    25699137
    SM4381
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    14 * 15 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    60 percent target mRNA inhibition
    25699137
    SM4395
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    14 * 15 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    96 percent target mRNA inhibition
    25699137
    SM4396
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    14 * 15 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    94 percent target mRNA inhibition
    25699137