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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

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• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 14 * 20,21 are 8
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4379	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Phosphate ; Sugar Sugar	67 percent target mRNA inhibition	25699137
SM4394	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Phosphate ; Sugar Sugar	88 percent target mRNA inhibition	25699137
SM4550	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	67 percent target mRNA inhibition	22260772
SM4551	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	38 percent target mRNA inhibition	22260772
SM4565	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	87 percent target mRNA inhibition	22260772
SM4566	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	93 percent target mRNA inhibition	22260772
SM4580	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	96 percent target mRNA inhibition	22260772
SM4581	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	97 percent target mRNA inhibition	22260772