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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


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• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 15 * 20,21 are 3
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4552	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	92 percent target mRNA inhibition	22260772
SM4567	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	91 percent target mRNA inhibition	22260772
SM4582	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	99 percent target mRNA inhibition	22260772