| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM2469 |
GCUGGGAUGCCUUUTT
AAAGGCAUCCCAGCCUCCGTT |
Assymetric siRNA (3-End Overhang)
Assymetric siRNA (3-End Overhang) |
16
1 |
NA
NA |
10 percent target mRNA inhibition | 23135004 |
| SM2657 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine
0 |
16
0 |
Sugar
0 |
85 percent target mRNA inhibition | 19233658 |
| SM3526 |
GGGAAACUGAAAGGCUAUGTT
CAUAGCCUUUCAGUUUCCCTT |
2-Deoxy-2-Fluoro
0 |
16
0 |
Sugar
0 |
50 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3566 |
AUCGACCUGAAGGAGUACGTT
CGUACUCCUUCAGGUCGAUTT |
2-Deoxy-2-Fluoro
2-Deoxy-2-Fluoro |
16
4 |
Sugar
Sugar |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3582 |
GAUUCCAAACCCCACUAUCTT
GAUAGUGGGGUUUGGAAUCTT |
2-O-Methyl
2-O-Methyl |
16
4 |
Sugar
Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3614 |
UCCCUUCCACCGCCAUAUUTT
AAUAUGGCGGUGGAAGGGATT |
2-O-Methyl
2-O-Methyl |
16
3 |
Sugar
Sugar |
49 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3842 |
CUGACCGGAAGCGCUUAAATT
UUUAAGCGCUUCCGGUCAGTT |
2-O-Methyl
2-O-Methyl |
16
3 |
Sugar
Sugar |
86 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3882 |
AUCAGAGGGAGGUCUUAGATT
UCUAAGACCUCCCUCUGAUTT |
2-O-Methyl
2-O-Methyl |
16
3 |
Sugar
Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM4070 |
AACCCAAAGGGGAGUUGCUTT
AGCAACUCCCCUUUGGGUUTT |
2-O-Methyl
2-O-Methyl |
16
14 |
Sugar
Sugar |
83 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM4130 |
GCUUCGGAAACUGGACAUCTT
GAUGUCCAGUUUCCGAAGCTT |
2-Deoxy-2-Fluoro
2-Deoxy-2-Fluoro |
16
3,7 |
Sugar
Sugar |
90 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |