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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 16,18 are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0017	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2-O-Methyl	16,18 2	Sugar Sugar	81.2 percent target mRNA inhibition	19282453
SM0063	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid 2-O-Methyl* 2-Aminoethyl	16,18 1 * 21	Sugar Sugar	90 percent target mRNA inhibition	19282453
SM0108	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid 2-O-Methyl* 2-Cyanoethyl	16,18 1 * 18	Sugar Sugar	53.5 percent target mRNA inhibition	19282453
SM0153	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid Altritol nucleic acid	16,18 1,2	Sugar Sugar	62.6 percent target mRNA inhibition	19282453
SM0198	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Altritol nucleic acid	16,18 20,21	Sugar Sugar	92.2 percent target mRNA inhibition	19282453
SM0243	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Altritol nucleic acid	16,18 5,8,11,14,17,20	Sugar Sugar	33.8 percent target mRNA inhibition	19282453
SM0288	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Altritol nucleic acid	16,18 3,6,14,18,20,21	Sugar Sugar	80.3 percent target mRNA inhibition	19282453
SM0333	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	16,18 18,19,20 * 21	Sugar Sugar	86 percent target mRNA inhibition	19282453
SM0378	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	16,18 2,18,19,20 * 21	Sugar Sugar	83.4 percent target mRNA inhibition	19282453
SM0423	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	16,18 3,18,19,20 * 21	Sugar Sugar	87.1 percent target mRNA inhibition	19282453
SM0468	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	16,18 2,9,18,19,20 * 21	Sugar Sugar	50.3 percent target mRNA inhibition	19282453
SM0513	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	16,18 18,19 * 21	Sugar Sugar	55.3 percent target mRNA inhibition	19282453
SM0558	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Oxetane-Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	16,18 18,19 * 21	Sugar Sugar	57.9 percent target mRNA inhibition	19282453
SM0603	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2-Fluoro* 2-O-Methyl	16,18 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	79.6 percent target mRNA inhibition	19282453
SM0648	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	16,18 3,18	Sugar Sugar	35.1 percent target mRNA inhibition	19282453
SM0693	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	16,18 4,18	Sugar Sugar	40.4 percent target mRNA inhibition	19282453
SM0738	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	16,18 3,4,18	Sugar Sugar	92.3 percent target mRNA inhibition	19282453
SM0783	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	16,18 3,18	Sugar Sugar	79.9 percent target mRNA inhibition	19282453
SM0828	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	16,18 4,18	Sugar Sugar	83.5 percent target mRNA inhibition	19282453
SM0873	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	16,18 3,4,18	Sugar Sugar	93.2 percent target mRNA inhibition	19282453
SM0918	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	16,18 3,18	Sugar Sugar	80.8 percent target mRNA inhibition	19282453
SM0963	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	16,18 4,18	Sugar Sugar	85.8 percent target mRNA inhibition	19282453
SM1008	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Oxetane-Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	16,18 3,4,18	Sugar Sugar	84.7 percent target mRNA inhibition	19282453
SM1053	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid 2-Aminoethyl	16,18 20,21	Sugar Sugar	89 percent target mRNA inhibition	19282453
SM1098	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid 2-Aminopropyl	16,18 1	Sugar Sugar	69.1 percent target mRNA inhibition	19282453



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