SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2468 |
GGCUGGGAUGCCUUUTT AAAGGCAUCCCAGCCUCCGTT |
Assymetric siRNA (3-End Overhang) Assymetric siRNA (3-End Overhang) |
17 1 |
NA NA |
16 percent target mRNA inhibition | 23135004 |
SM2607 |
GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU |
2-O-Allyl-ribose 2-O-Aminoethyl-ribose |
17 20,21 |
Sugar Sugar |
73 percent target mRNA inhibition | 17904849 |
SM2610 |
GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU |
2-O-Allyl-ribose 2-O-Aminoethyl-ribose |
17 1,20,21 |
Sugar Sugar |
20 percent target mRNA inhibition | 17904849 |
SM3590 |
AGAGAAGGGCGUCUCUACATT UGUAGAGACGCCCUUCUCUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
17 3 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3654 |
CUCCCCAGUCUCUCUUAAATT UUUAAGAGAGACUGGGGAGTT |
2-O-Methyl 2-O-Methyl |
17 4 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3754 |
CUCCUUCAUUCCAGCCUAUTT AUAGGCUGGAAUGAAGGAGTT |
2-O-Methyl 2-O-Methyl |
17 2 |
Sugar Sugar |
81 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3866 |
CUCUGGCCUUUCUCUCUAGTT CUAGAGAGAAAGGCCAGAGTT |
2-O-Methyl 0 |
17 0 |
Sugar 0 |
47 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3910 |
UCCUCGUCGUCUGUUCUAATT UUAGAACAGACGACGAGGATT |
2-O-Methyl 2-O-Methyl |
17 2 |
Sugar Sugar |
84 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4102 |
AACUUCUGGGAGCCUCCAATT UUGGAGGCUCCCAGAAGUUTT |
2-O-Methyl 2-O-Methyl |
17 12 |
Sugar Sugar |
73 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4190 |
UCCUCGUCGUCUGUUCUAATT UUAGAACAGACGACGAGGATT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
17 2,7 |
Sugar Sugar |
74 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4598 |
GGCCUUUCACUACUCCUACTT AGUAGGAGUAGUGAAAGGCCTT |
4-C- Aminomethyl-2-O-Methylribose 0 |
17 0 |
Sugar 0 |
93 percent target mRNA inhibition | 22372696 |