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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 17 * 20,21 are 5
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4512
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    17 * 20,21
    20,21
    Sugar
    Sugar
    59 percent target mRNA inhibition
    17616127
    SM4524
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    17 * 20,21
    12 * 20,21
    Sugar
    Sugar
    42 percent target mRNA inhibition
    17616127
    SM4525
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    17 * 20,21
    12 * 20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    17616127
    SM4590
    GGUCAUCCAUGACAACUUUTT
    AAAGUUGUCAUGGAUGACCTT
    Triazole-linked nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    17 * 20,21
    20,21
    Sugar; Backbone
    Sugar
    86 percent target mRNA inhibition
    22260772
    SM4594
    GGUCAUCCAUGACAACUUUTT
    AAAGUUGUCAUGGAUGACCTT
    Triazole-linked nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    17 * 20,21
    20,21
    Sugar; Backbone
    Sugar
    96 percent target mRNA inhibition
    22260772