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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 18 are 104
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0001	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-O-Methyl	18 2	Sugar Sugar	69.5 percent target mRNA inhibition	19282453
SM0002	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-O-Methyl	18 2	Sugar Sugar	76.8 percent target mRNA inhibition	19282453
SM0047	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-O-Methyl* 2-Aminoethyl	18 1 * 21	Sugar Sugar	85.3 percent target mRNA inhibition	19282453
SM0048	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-O-Methyl* 2-Aminoethyl	18 1 * 21	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0092	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-O-Methyl* 2-Cyanoethyl	18 1 * 18	Sugar Sugar	54.8 percent target mRNA inhibition	19282453
SM0093	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-O-Methyl* 2-Cyanoethyl	18 1 * 18	Sugar Sugar	55 percent target mRNA inhibition	19282453
SM0137	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl Altritol nucleic acid	18 1,2	Sugar Sugar	57 percent target mRNA inhibition	19282453
SM0138	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl Altritol nucleic acid	18 1,2	Sugar Sugar	56.1 percent target mRNA inhibition	19282453
SM0182	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	18 20,21	Sugar Sugar	93.3 percent target mRNA inhibition	19282453
SM0183	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 20,21	Sugar Sugar	88.8 percent target mRNA inhibition	19282453
SM0227	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	18 5,8,11,14,17,20	Sugar Sugar	41.9 percent target mRNA inhibition	19282453
SM0228	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 5,8,11,14,17,20	Sugar Sugar	19.2 percent target mRNA inhibition	19282453
SM0272	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	18 3,6,14,18,20,21	Sugar Sugar	82.3 percent target mRNA inhibition	19282453
SM0273	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 3,6,14,18,20,21	Sugar Sugar	78.4 percent target mRNA inhibition	19282453
SM0317	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	18 18,19,20 * 21	Sugar Sugar	87.5 percent target mRNA inhibition	19282453
SM0318	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 18,19,20 * 21	Sugar Sugar	84.8 percent target mRNA inhibition	19282453
SM0362	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	18 2,18,19,20 * 21	Sugar Sugar	73.8 percent target mRNA inhibition	19282453
SM0363	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 2,18,19,20 * 21	Sugar Sugar	78.5 percent target mRNA inhibition	19282453
SM0407	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	18 3,18,19,20 * 21	Sugar Sugar	80.9 percent target mRNA inhibition	19282453
SM0408	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 3,18,19,20 * 21	Sugar Sugar	78.5 percent target mRNA inhibition	19282453
SM0452	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	18 2,9,18,19,20 * 21	Sugar Sugar	42 percent target mRNA inhibition	19282453
SM0453	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 2,9,18,19,20 * 21	Sugar Sugar	42.2 percent target mRNA inhibition	19282453
SM0497	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl 2-Aminoethoxymethyl* 2-Deoxy	18 18,19 * 21	Sugar Sugar	46 percent target mRNA inhibition	19282453
SM0498	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl 2-Aminoethoxymethyl* 2-Deoxy	18 18,19 * 21	Sugar Sugar	49.1 percent target mRNA inhibition	19282453
SM0542	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl 2-Aminopropoxymethyl* 2-Deoxy	18 18,19 * 21	Sugar Sugar	61.5 percent target mRNA inhibition	19282453



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