| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0006 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl |
18,19 * 22
2 |
Sugar
Sugar |
71.3 percent target mRNA inhibition | 19282453 |
| SM0052 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl* 2-Aminoethyl |
18,19 * 22
1 * 21 |
Sugar
Sugar |
74 percent target mRNA inhibition | 19282453 |
| SM0097 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-O-Methyl* 2-Cyanoethyl |
18,19 * 22
1 * 18 |
Sugar
Sugar |
33.7 percent target mRNA inhibition | 19282453 |
| SM0142 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
18,19 * 22
1,2 |
Sugar
Sugar |
51.6 percent target mRNA inhibition | 19282453 |
| SM0187 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
18,19 * 22
20,21 |
Sugar
Sugar |
90.5 percent target mRNA inhibition | 19282453 |
| SM0232 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
18,19 * 22
5,8,11,14,17,20 |
Sugar
Sugar |
7.8 percent target mRNA inhibition | 19282453 |
| SM0277 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
Altritol nucleic acid |
18,19 * 22
3,6,14,18,20,21 |
Sugar
Sugar |
76 percent target mRNA inhibition | 19282453 |
| SM0322 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
18,19 * 22
18,19,20 * 21 |
Sugar
Sugar |
84.2 percent target mRNA inhibition | 19282453 |
| SM0367 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
18,19 * 22
2,18,19,20 * 21 |
Sugar
Sugar |
63.8 percent target mRNA inhibition | 19282453 |
| SM0412 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
18,19 * 22
3,18,19,20 * 21 |
Sugar
Sugar |
75.6 percent target mRNA inhibition | 19282453 |
| SM0457 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
18,19 * 22
2,9,18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0502 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminoethoxymethyl* 2-Deoxy |
18,19 * 22
18,19 * 21 |
Sugar
Sugar |
30.7 percent target mRNA inhibition | 19282453 |
| SM0547 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
18,19 * 22
18,19 * 21 |
Sugar
Sugar |
24.6 percent target mRNA inhibition | 19282453 |
| SM0592 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Fluoro* 2-O-Methyl |
18,19 * 22
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 |
Sugar
Sugar |
67.1 percent target mRNA inhibition | 19282453 |
| SM0637 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
18,19 * 22
3,18 |
Sugar
Sugar |
43.9 percent target mRNA inhibition | 19282453 |
| SM0682 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
18,19 * 22
4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0727 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
18,19 * 22
3,4,18 |
Sugar
Sugar |
87.9 percent target mRNA inhibition | 19282453 |
| SM0772 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
18,19 * 22
3,18 |
Sugar
Sugar |
73.5 percent target mRNA inhibition | 19282453 |
| SM0817 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
18,19 * 22
4,18 |
Sugar
Sugar |
50 percent target mRNA inhibition | 19282453 |
| SM0862 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
18,19 * 22
3,4,18 |
Sugar
Sugar |
89.9 percent target mRNA inhibition | 19282453 |
| SM0907 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
18,19 * 22
3,18 |
Sugar
Sugar |
76.2 percent target mRNA inhibition | 19282453 |
| SM0952 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
18,19 * 22
4,18 |
Sugar
Sugar |
52.3 percent target mRNA inhibition | 19282453 |
| SM0997 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGC |
Altritol nucleic acid* 2-Deoxy
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
18,19 * 22
3,4,18 |
Sugar
Sugar |
78.1 percent target mRNA inhibition | 19282453 |
| SM1042 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-Aminoethyl |
18,19 * 22
20,21 |
Sugar
Sugar |
90.7 percent target mRNA inhibition | 19282453 |
| SM1087 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
2-Aminopropyl |
18,19 * 22
1 |
Sugar
Sugar |
46.6 percent target mRNA inhibition | 19282453 |