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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 19 are 60
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0021	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-O-Methyl	19 2	Sugar Sugar	66.4 percent target mRNA inhibition	19282453
SM0067	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-O-Methyl* 2-Aminoethyl	19 1 * 21	Sugar Sugar	75 percent target mRNA inhibition	19282453
SM0112	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-O-Methyl* 2-Cyanoethyl	19 1 * 18	Sugar Sugar	43 percent target mRNA inhibition	19282453
SM0157	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl Altritol nucleic acid	19 1,2	Sugar Sugar	56.3 percent target mRNA inhibition	19282453
SM0202	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	19 20,21	Sugar Sugar	88.9 percent target mRNA inhibition	19282453
SM0247	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	19 5,8,11,14,17,20	Sugar Sugar	11.1 percent target mRNA inhibition	19282453
SM0292	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Altritol nucleic acid	19 3,6,14,18,20,21	Sugar Sugar	78.3 percent target mRNA inhibition	19282453
SM0337	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	19 18,19,20 * 21	Sugar Sugar	85.4 percent target mRNA inhibition	19282453
SM0382	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	19 2,18,19,20 * 21	Sugar Sugar	74.2 percent target mRNA inhibition	19282453
SM0427	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	19 3,18,19,20 * 21	Sugar Sugar	76.7 percent target mRNA inhibition	19282453
SM0472	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl Hexitol nucleic acid* 2-Deoxy	19 2,9,18,19,20 * 21	Sugar Sugar	18.8 percent target mRNA inhibition	19282453
SM0517	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl 2-Aminoethoxymethyl* 2-Deoxy	19 18,19 * 21	Sugar Sugar	29.6 percent target mRNA inhibition	19282453
SM0562	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Aminoethyl 2-Aminopropoxymethyl* 2-Deoxy	19 18,19 * 21	Sugar Sugar	6 percent target mRNA inhibition	19282453
SM0607	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-Fluoro* 2-O-Methyl	19 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	65.4 percent target mRNA inhibition	19282453
SM0652	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	19 3,18	Sugar Sugar	49.4 percent target mRNA inhibition	19282453
SM0697	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	19 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0742	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	19 3,4,18	Sugar Sugar	86.6 percent target mRNA inhibition	19282453
SM0787	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	19 3,18	Sugar Sugar	78.6 percent target mRNA inhibition	19282453
SM0832	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	19 4,18	Sugar Sugar	45 percent target mRNA inhibition	19282453
SM0877	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	19 3,4,18	Sugar Sugar	88.8 percent target mRNA inhibition	19282453
SM0922	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	19 3,18	Sugar Sugar	74.4 percent target mRNA inhibition	19282453
SM0967	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	19 4,18	Sugar Sugar	56 percent target mRNA inhibition	19282453
SM1012	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Aminoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	19 3,4,18	Sugar Sugar	72.2 percent target mRNA inhibition	19282453
SM1057	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-Aminoethyl	19 20,21	Sugar Sugar	90.7 percent target mRNA inhibition	19282453
SM1102	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl 2-Aminopropyl	19 1	Sugar Sugar	54.7 percent target mRNA inhibition	19282453



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