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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 19,20 are 96
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0009	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-O-Methyl	19,20 2	Sugar Sugar	57 percent target mRNA inhibition	19282453
SM0024	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl	19,20 2	Sugar Sugar	74 percent target mRNA inhibition	19282453
SM0055	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-O-Methyl* 2-Aminoethyl	19,20 1 * 21	Sugar Sugar	72 percent target mRNA inhibition	19282453
SM0070	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl* 2-Aminoethyl	19,20 1 * 21	Sugar Sugar	81 percent target mRNA inhibition	19282453
SM0100	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-O-Methyl* 2-Cyanoethyl	19,20 1 * 18	Sugar Sugar	28.3 percent target mRNA inhibition	19282453
SM0115	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl* 2-Cyanoethyl	19,20 1 * 18	Sugar Sugar	37.8 percent target mRNA inhibition	19282453
SM0145	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid Altritol nucleic acid	19,20 1,2	Sugar Sugar	44.6 percent target mRNA inhibition	19282453
SM0160	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	19,20 1,2	Sugar Sugar	47.4 percent target mRNA inhibition	19282453
SM0190	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	19,20 20,21	Sugar Sugar	93.6 percent target mRNA inhibition	19282453
SM0205	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	19,20 20,21	Sugar Sugar	86.6 percent target mRNA inhibition	19282453
SM0235	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	19,20 5,8,11,14,17,20	Sugar Sugar	37.7 percent target mRNA inhibition	19282453
SM0250	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	19,20 5,8,11,14,17,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0280	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	19,20 3,6,14,18,20,21	Sugar Sugar	74.9 percent target mRNA inhibition	19282453
SM0295	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	19,20 3,6,14,18,20,21	Sugar Sugar	71.7 percent target mRNA inhibition	19282453
SM0325	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 18,19,20 * 21	Sugar Sugar	80.4 percent target mRNA inhibition	19282453
SM0340	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 18,19,20 * 21	Sugar Sugar	81.4 percent target mRNA inhibition	19282453
SM0370	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 2,18,19,20 * 21	Sugar Sugar	65.9 percent target mRNA inhibition	19282453
SM0385	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 2,18,19,20 * 21	Sugar Sugar	77.6 percent target mRNA inhibition	19282453
SM0415	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 3,18,19,20 * 21	Sugar Sugar	70.9 percent target mRNA inhibition	19282453
SM0430	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 3,18,19,20 * 21	Sugar Sugar	78.8 percent target mRNA inhibition	19282453
SM0460	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 2,9,18,19,20 * 21	Sugar Sugar	1.1 percent target mRNA inhibition	19282453
SM0475	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	19,20 2,9,18,19,20 * 21	Sugar Sugar	27.2 percent target mRNA inhibition	19282453
SM0505	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	19,20 18,19 * 21	Sugar Sugar	9.9 percent target mRNA inhibition	19282453
SM0520	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Aminoethoxymethyl* 2-Deoxy	19,20 18,19 * 21	Sugar Sugar	33.3 percent target mRNA inhibition	19282453
SM0550	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	19,20 18,19 * 21	Sugar Sugar	45.6 percent target mRNA inhibition	19282453



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