| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0013 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGC |
2-Aminoethoxymethyl* 2-Deoxy
2-O-Methyl |
19,20 * 21
2 |
Sugar
Sugar |
79.7 percent target mRNA inhibition | 19282453 |
| SM0015 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGC |
2-Aminopropoxymethyl* 2-Deoxy
2-O-Methyl |
19,20 * 21
2 |
Sugar
Sugar |
80.6 percent target mRNA inhibition | 19282453 |
| SM0059 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
2-O-Methyl* 2-Aminoethyl |
19,20 * 21
1 * 21 |
Sugar
Sugar |
85 percent target mRNA inhibition | 19282453 |
| SM0061 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
2-O-Methyl* 2-Aminoethyl |
19,20 * 21
1 * 21 |
Sugar
Sugar |
84 percent target mRNA inhibition | 19282453 |
| SM0104 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
2-O-Methyl* 2-Cyanoethyl |
19,20 * 21
1 * 18 |
Sugar
Sugar |
55.4 percent target mRNA inhibition | 19282453 |
| SM0106 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
2-O-Methyl* 2-Cyanoethyl |
19,20 * 21
1 * 18 |
Sugar
Sugar |
60.3 percent target mRNA inhibition | 19282453 |
| SM0149 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGC |
2-Aminoethoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
1,2 |
Sugar
Sugar |
61.1 percent target mRNA inhibition | 19282453 |
| SM0151 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGC |
2-Aminopropoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
1,2 |
Sugar
Sugar |
63.5 percent target mRNA inhibition | 19282453 |
| SM0194 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
20,21 |
Sugar
Sugar |
88.2 percent target mRNA inhibition | 19282453 |
| SM0196 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
20,21 |
Sugar
Sugar |
88.5 percent target mRNA inhibition | 19282453 |
| SM0239 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
5,8,11,14,17,20 |
Sugar
Sugar |
12.7 percent target mRNA inhibition | 19282453 |
| SM0241 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
5,8,11,14,17,20 |
Sugar
Sugar |
12.6 percent target mRNA inhibition | 19282453 |
| SM0284 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
3,6,14,18,20,21 |
Sugar
Sugar |
79.6 percent target mRNA inhibition | 19282453 |
| SM0286 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
Altritol nucleic acid |
19,20 * 21
3,6,14,18,20,21 |
Sugar
Sugar |
77.5 percent target mRNA inhibition | 19282453 |
| SM0329 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
86.3 percent target mRNA inhibition | 19282453 |
| SM0331 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
84.6 percent target mRNA inhibition | 19282453 |
| SM0374 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
2,18,19,20 * 21 |
Sugar
Sugar |
77 percent target mRNA inhibition | 19282453 |
| SM0376 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
2,18,19,20 * 21 |
Sugar
Sugar |
78.9 percent target mRNA inhibition | 19282453 |
| SM0419 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
3,18,19,20 * 21 |
Sugar
Sugar |
82.7 percent target mRNA inhibition | 19282453 |
| SM0421 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
3,18,19,20 * 21 |
Sugar
Sugar |
82.8 percent target mRNA inhibition | 19282453 |
| SM0464 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
2,9,18,19,20 * 21 |
Sugar
Sugar |
50 percent target mRNA inhibition | 19282453 |
| SM0466 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
2,9,18,19,20 * 21 |
Sugar
Sugar |
50.4 percent target mRNA inhibition | 19282453 |
| SM0509 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
2-Aminoethoxymethyl* 2-Deoxy |
19,20 * 21
18,19 * 21 |
Sugar
Sugar |
60.1 percent target mRNA inhibition | 19282453 |
| SM0511 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
2-Aminoethoxymethyl* 2-Deoxy |
19,20 * 21
18,19 * 21 |
Sugar
Sugar |
63.7 percent target mRNA inhibition | 19282453 |
| SM0554 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
19,20 * 21
18,19 * 21 |
Sugar
Sugar |
50.7 percent target mRNA inhibition | 19282453 |