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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 20,21 are 320
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0008
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    64.5 percent target mRNA inhibition
    19282453
    SM0033
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    80 percent target mRNA inhibition
    19282453
    SM0035
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Alfa-L-Locked nucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0044
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    81 percent target mRNA inhibition
    19282453
    SM0054
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0079
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    88 percent target mRNA inhibition
    19282453
    SM0081
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    80.4 percent target mRNA inhibition
    19282453
    SM0090
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    82.3 percent target mRNA inhibition
    19282453
    SM0099
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    24.7 percent target mRNA inhibition
    19282453
    SM0124
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    48.9 percent target mRNA inhibition
    19282453
    SM0126
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    45.2 percent target mRNA inhibition
    19282453
    SM0135
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    57.3 percent target mRNA inhibition
    19282453
    SM0144
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    36.7 percent target mRNA inhibition
    19282453
    SM0169
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    59.4 percent target mRNA inhibition
    19282453
    SM0171
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Alfa-L-Locked nucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    54.8 percent target mRNA inhibition
    19282453
    SM0180
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    60.5 percent target mRNA inhibition
    19282453
    SM0189
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    87.1 percent target mRNA inhibition
    19282453
    SM0214
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    91.3 percent target mRNA inhibition
    19282453
    SM0216
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    Altritol nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    88.4 percent target mRNA inhibition
    19282453
    SM0225
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    88 percent target mRNA inhibition
    19282453
    SM0234
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0259
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    24 percent target mRNA inhibition
    19282453
    SM0261
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    Altritol nucleic acid
    20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    13.1 percent target mRNA inhibition
    19282453
    SM0270
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    6.5 percent target mRNA inhibition
    19282453
    SM0279
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    70.3 percent target mRNA inhibition
    19282453