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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22,23 * 1* 23 are 5
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2512
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine* 5-Amino * 3-Amino
    22,23 * 1* 23
    22,23 * 1* 23
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2514
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxyribonucleotide* Inverted abasic
    22,23 * 1* 23
    22,23 * 23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2515
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine * 3-Amino
    22,23 * 1* 23
    22,23 * 23
    Sugar
    Phosphate; Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2516
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine* 5-Amino * 3-Amino
    2-Deoxythymidine
    22,23 * 1* 23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2517
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine* 5-Amino * 3-Amino
    0
    22,23 * 1* 23
    0
    Sugar
    0
    High target mRNA inhibition efficacy
    12771196