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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for 4,16 are 4
Results from 0 - 25
| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM3625 |
AGUUAACCCGGGACUUGGATT
UCCAAGUCCCGGGUUAACUTT |
2-Deoxy-2-Fluoro
2-Deoxy-2-Fluoro |
4,16
3,15 |
Sugar
Sugar |
85 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM3626 |
AGUUAACCCGGGACUUGGATT
UCCAAGUCCCGGGUUAACUTT |
2-Deoxy-2-Fluoro
2-Deoxy-2-Fluoro |
4,16
3,15 |
Sugar
Sugar |
86 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM4049 |
AGUUAACCCGGGACUUGGATT
UCCAAGUCCCGGGUUAACUTT |
2-O-Methyl
2-O-Methyl |
4,16
3,15 |
Sugar
Sugar |
90 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
| SM4082 |
GAAUAACCUGAACGUCACCTT
GGUGACGUUCAGGUUAUUCTT |
2-O-Methyl
2-O-Methyl |
4,16
10 |
Sugar
Sugar |
71 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |