| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0039 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl |
5 * 20,21
2 |
Sugar
Sugar |
11 percent target mRNA inhibition | 19282453 |
| SM0085 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl* 2-Aminoethyl |
5 * 20,21
1 * 21 |
Sugar
Sugar |
9.6 percent target mRNA inhibition | 19282453 |
| SM0130 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl* 2-Cyanoethyl |
5 * 20,21
1 * 18 |
Sugar
Sugar |
0.9 percent target mRNA inhibition | 19282453 |
| SM0175 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
5 * 20,21
1,2 |
Sugar
Sugar |
8.3 percent target mRNA inhibition | 19282453 |
| SM0220 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
5 * 20,21
20,21 |
Sugar
Sugar |
85.4 percent target mRNA inhibition | 19282453 |
| SM0265 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
5 * 20,21
5,8,11,14,17,20 |
Sugar
Sugar |
5.7 percent target mRNA inhibition | 19282453 |
| SM0310 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
5 * 20,21
3,6,14,18,20,21 |
Sugar
Sugar |
44.2 percent target mRNA inhibition | 19282453 |
| SM0355 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
5 * 20,21
18,19,20 * 21 |
Sugar
Sugar |
45.1 percent target mRNA inhibition | 19282453 |
| SM0400 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
5 * 20,21
2,18,19,20 * 21 |
Sugar
Sugar |
8.7 percent target mRNA inhibition | 19282453 |
| SM0445 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
5 * 20,21
3,18,19,20 * 21 |
Sugar
Sugar |
19.5 percent target mRNA inhibition | 19282453 |
| SM0490 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
5 * 20,21
2,9,18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0535 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
2-Aminoethoxymethyl* 2-Deoxy |
5 * 20,21
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0580 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
5 * 20,21
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0625 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Fluoro* 2-O-Methyl |
5 * 20,21
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 |
Sugar
Sugar |
17 percent target mRNA inhibition | 19282453 |
| SM0670 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
5 * 20,21
3,18 |
Sugar
Sugar |
17.2 percent target mRNA inhibition | 19282453 |
| SM0715 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
5 * 20,21
4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0760 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
5 * 20,21
3,4,18 |
Sugar
Sugar |
54.5 percent target mRNA inhibition | 19282453 |
| SM0805 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
5 * 20,21
3,18 |
Sugar
Sugar |
37.5 percent target mRNA inhibition | 19282453 |
| SM0850 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
5 * 20,21
4,18 |
Sugar
Sugar |
0.3 percent target mRNA inhibition | 19282453 |
| SM0895 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
5 * 20,21
3,4,18 |
Sugar
Sugar |
67.1 percent target mRNA inhibition | 19282453 |
| SM0940 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
5 * 20,21
3,18 |
Sugar
Sugar |
48.3 percent target mRNA inhibition | 19282453 |
| SM0985 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
5 * 20,21
4,18 |
Sugar
Sugar |
7.4 percent target mRNA inhibition | 19282453 |
| SM1030 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
5 * 20,21
3,4,18 |
Sugar
Sugar |
40.7 percent target mRNA inhibition | 19282453 |
| SM1075 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-Aminoethyl |
5 * 20,21
20,21 |
Sugar
Sugar |
79.2 percent target mRNA inhibition | 19282453 |
| SM1120 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-Aminopropyl |
5 * 20,21
1 |
Sugar
Sugar |
17.5 percent target mRNA inhibition | 19282453 |