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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 9 * 10 * 20,21 are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4377
    CUUACGCUCUGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    9 * 10 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    50 percent target mRNA inhibition
    25699137
    SM4378
    CUUACGCUCUGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    9 * 10 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    44 percent target mRNA inhibition
    25699137
    SM4392
    CUUACGCUCUGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    9 * 10 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    90 percent target mRNA inhibition
    25699137
    SM4393
    CUUACGCUCUGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    9 * 10 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    86 percent target mRNA inhibition
    25699137