Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 20610434 are 62
    Results from 25 - 50
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2802
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy-2-Aminopurine-2-Deoxyribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2803
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy-2-Aminopurine-2-Deoxyribonucleotide
    0
    11
    0
    Base
    0
    NA
    20610434
    SM2804
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy-2-Aminopurine-2-Deoxyribonucleotide
    0
    12
    0
    Base
    0
    NA
    20610434
    SM2805
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Aminopurineribonucleotide
    0
    9
    0
    Base
    0
    NA
    20610434
    SM2806
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Aminopurineribonucleotide
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2807
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Aminopurineribonucleotide
    0
    11
    0
    Base
    0
    NA
    20610434
    SM2808
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Aminopurineribonucleotide
    0
    12
    0
    Base
    0
    NA
    20610434
    SM2809
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxyinosine
    0
    9
    0
    Base
    0
    NA
    20610434
    SM2810
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxyinosine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2811
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxyinosine
    0
    11
    0
    Base
    0
    NA
    20610434
    SM2812
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxyinosine
    0
    12
    0
    Base
    0
    NA
    20610434
    SM2813
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Inosine
    0
    9
    0
    Base
    0
    NA
    20610434
    SM2814
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Inosine
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2815
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Inosine
    0
    11
    0
    Base
    0
    NA
    20610434
    SM2816
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Inosine
    0
    12
    0
    Base
    0
    NA
    20610434
    SM2817
    AUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAUTT
    Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol)
    0
    9
    0
    Base
    0
    NA
    20610434
    SM2818
    GUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAACTT
    Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol)
    0
    10
    0
    Base
    0
    NA
    20610434
    SM2819
    UUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAATT
    Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol)
    0
    11
    0
    Base
    0
    NA
    20610434
    SM2820
    CAUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAUGTT
    Abasic(2-hydroxymethyl-tetrahydrofuran-3-ol)
    0
    12
    0
    Base
    0
    NA
    20610434
    SM2822
    CCUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* Phosphorothioate
    0
    2 * 9
    0
    Base; Phosphate
    0
    IC-50 = 0.48 nM for target mRNA
    20610434
    SM2823
    CCUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* 2-O-Methyl
    0
    2 * 9
    0
    Base; Sugar
    0
    IC-50 = 0.341 nM for target mRNA
    20610434
    SM2824
    CUAACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* 2-O-Methyl* Phosphorothioate
    0
    3 * 9 * 9
    0
    Base; Sugar; Phosphate
    0
    IC-50 = 0.336 nM for target mRNA
    20610434
    SM2825
    CUCACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* Phosphorothioate* 2,4-Difluorotoluene
    0
    3 * 9 * 10
    0
    Base; Phosphate; Base
    0
    IC-50 = 0.131 nM for target mRNA
    20610434
    SM2826
    CUCACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* 2-O-Methyl* Phosphorothioate* 2,4-Difluorotoluene
    0
    3 * 9 * 9 * 10
    0
    Sugar; Phosphate; Base
    0
    IC-50 = 0.111 nM for target mRNA
    20610434
    SM2828
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2-O-Methyl
    0
    9
    0
    Sugar
    0
    IC-50 = 0.146 nM for target mRNA
    20610434