SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4709 |
NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN |
2-O-Methyl 0 |
1,2,11,13 0 |
Sugar 0 |
0 percent target mRNA inhibition | EP2548962A1 |
SM4830 |
UGAAUCAGAAGAUGAAGUCAA GACUUCAUCUUCUGAUUCAAG |
unlocked nucleic acid 0 |
1 0 |
Sugar 0 |
85 percent target mRNA inhibition | 23820891 |
SM4834 |
UGAAUCAGAAGAUGAAGUCAA GACUUCAUCUUCUGAUUCAAG |
unlocked nucleic acid 0 |
1 0 |
Sugar 0 |
50 percent target mRNA inhibition | 23820891 |
SM4857 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
3,12,15,16 0 |
Sugar 0 |
96.3 percent target mRNA inhibition | 15919084 |
SM4858 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,5,7,14,17 0 |
Sugar 0 |
93.6 percent target mRNA inhibition | 15919084 |
SM4859 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,3,5,7,12,14,15,16,17 0 |
Sugar 0 |
92.9 percent target mRNA inhibition (IC-50 = 0.12 nM) | 15919084 |
SM4860 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 0 |
Sugar 0 |
60.3 percent target mRNA inhibition | 15919084 |
SM4865 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6 0 |
Sugar 0 |
94 percent target mRNA inhibition | 15919084 |
SM4866 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
14,15,16,17,18,19 0 |
Sugar 0 |
93.8 percent target mRNA inhibition | 15919084 |
SM4867 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
7,8,9,10,11,12,13 0 |
Sugar 0 |
87.4 percent target mRNA inhibition (IC-50 = 0.31 nM) | 15919084 |
SM4868 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6,14,15,16,17,18,19 0 |
Sugar 0 |
91.5 percent target mRNA inhibition (IC-50 = 0.16 nM) | 15919084 |
SM4873 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
2-O-Methyl 0 |
1,2,3,4,5,6 0 |
Sugar 0 |
94.8 percent target mRNA inhibition | 15919084 |
SM4874 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
2-O-Methyl 0 |
14,15,16,17,18,19 0 |
Sugar 0 |
94.2 percent target mRNA inhibition | 15919084 |
SM4878 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
95.5 percent target mRNA inhibition | 17150641 |
SM4879 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
94.2 percent target mRNA inhibition | 17150641 |
SM4880 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,16,17,18,19 0 |
Sugar 0 |
94.7 percent target mRNA inhibition | 17150641 |
SM4886 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
69.5 percent target mRNA inhibition | 17150641 |
SM4887 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
70.4 percent target mRNA inhibition | 17150641 |
SM4888 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2,3,4,16,17,18,19 0 |
Sugar 0 |
79.1 percent target mRNA inhibition | 17150641 |
SM4894 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
14,15,16,17,18,19 0 |
Sugar 0 |
93.8 percent target mRNA inhibition | 17924376 |
SM4895 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
16,17,18,19 0 |
Sugar 0 |
94.3 percent target mRNA inhibition | 17924376 |
SM4896 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
18,19 0 |
Sugar 0 |
95.4 percent target mRNA inhibition | 17924376 |
SM4897 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6 0 |
Sugar 0 |
94 percent target mRNA inhibition | 17924376 |
SM4898 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
94.2 percent target mRNA inhibition | 17924376 |
SM4899 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
95.5 percent target mRNA inhibition | 17924376 |