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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Aminoethyl are 45
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1037
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    18
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1038
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-Aminoethyl
    18
    20,21
    Sugar
    Sugar
    88.9 percent target mRNA inhibition
    19282453
    SM1039
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminoethyl
    2,8,14,17
    20,21
    Sugar
    Sugar
    85 percent target mRNA inhibition
    19282453
    SM1040
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminoethyl
    5,8,14,17,22
    20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    19282453
    SM1041
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminoethyl
    1,2 * 22
    20,21
    Sugar
    Sugar
    90.4 percent target mRNA inhibition
    19282453
    SM1042
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminoethyl
    18,19 * 22
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1043
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminoethyl
    5,8,11,14,17 * 22
    20,21
    Sugar
    Sugar
    56.5 percent target mRNA inhibition
    19282453
    SM1044
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-Aminoethyl
    20,21
    20,21
    Sugar
    Sugar
    84.8 percent target mRNA inhibition
    19282453
    SM1045
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminoethyl
    19,20
    20,21
    Sugar
    Sugar
    90.2 percent target mRNA inhibition
    19282453
    SM1046
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminoethyl
    1,2,3,18,19,20 * 21
    20,21
    Sugar
    Sugar
    88.6 percent target mRNA inhibition
    19282453
    SM1047
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminoethyl
    5,8,11,14 * 21
    20,21
    Sugar
    Sugar
    69.8 percent target mRNA inhibition
    19282453
    SM1048
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminoethyl
    5,8,11,14,19,20 * 21
    20,21
    Sugar
    Sugar
    88.6 percent target mRNA inhibition
    19282453
    SM1049
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-Aminoethyl
    19,20 * 21
    20,21
    Sugar
    Sugar
    88.8 percent target mRNA inhibition
    19282453
    SM1050
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-Aminoethyl
    3,5,9,19,20 * 21
    20,21
    Sugar
    Sugar
    89.8 percent target mRNA inhibition
    19282453
    SM1051
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-Aminoethyl
    19,20 * 21
    20,21
    Sugar
    Sugar
    88.1 percent target mRNA inhibition
    19282453
    SM1052
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-Aminoethyl
    3,5,9,19,20 * 21
    20,21
    Sugar
    Sugar
    82.6 percent target mRNA inhibition
    19282453
    SM1053
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-Aminoethyl
    16,18
    20,21
    Sugar
    Sugar
    89 percent target mRNA inhibition
    19282453
    SM1054
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-Aminoethyl
    2,4
    20,21
    Sugar
    Sugar
    89.1 percent target mRNA inhibition
    19282453
    SM1055
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    2-Aminoethyl
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    20,21
    Sugar
    Sugar
    88.6 percent target mRNA inhibition
    19282453
    SM1056
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    20
    20,21
    Sugar
    Sugar
    89.7 percent target mRNA inhibition
    19282453
    SM1057
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    19
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1058
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    5,19,20
    20,21
    Sugar
    Sugar
    89 percent target mRNA inhibition
    19282453
    SM1059
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,9,15,20,21
    20,21
    Sugar
    Sugar
    89.7 percent target mRNA inhibition
    19282453
    SM1060
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminoethyl
    19,20
    20,21
    Sugar
    Sugar
    85.7 percent target mRNA inhibition
    19282453
    SM1061
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminoethyl
    5,19,20
    20,21
    Sugar
    Sugar
    90.1 percent target mRNA inhibition
    19282453