| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0542 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
2-Aminopropoxymethyl* 2-Deoxy |
18
18,19 * 21 |
Sugar
Sugar |
61.5 percent target mRNA inhibition | 19282453 |
| SM0543 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Guanidinoethyl
2-Aminopropoxymethyl* 2-Deoxy |
18
18,19 * 21 |
Sugar
Sugar |
36.2 percent target mRNA inhibition | 19282453 |
| SM0544 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
2,8,14,17
18,19 * 21 |
Sugar
Sugar |
1.9 percent target mRNA inhibition | 19282453 |
| SM0545 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
5,8,14,17,22
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0546 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
1,2 * 22
18,19 * 21 |
Sugar
Sugar |
47.5 percent target mRNA inhibition | 19282453 |
| SM0547 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
18,19 * 22
18,19 * 21 |
Sugar
Sugar |
24.6 percent target mRNA inhibition | 19282453 |
| SM0548 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
5,8,11,14,17 * 22
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0549 |
GACGUAAACGGCCACAAGUUCU
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
20,21
18,19 * 21 |
Sugar
Sugar |
3.2 percent target mRNA inhibition | 19282453 |
| SM0550 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
19,20
18,19 * 21 |
Sugar
Sugar |
45.6 percent target mRNA inhibition | 19282453 |
| SM0551 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
1,2,3,18,19,20 * 21
18,19 * 21 |
Sugar
Sugar |
54 percent target mRNA inhibition | 19282453 |
| SM0552 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
5,8,11,14 * 21
18,19 * 21 |
Sugar
Sugar |
2.5 percent target mRNA inhibition | 19282453 |
| SM0553 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
5,8,11,14,19,20 * 21
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0554 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
19,20 * 21
18,19 * 21 |
Sugar
Sugar |
50.7 percent target mRNA inhibition | 19282453 |
| SM0555 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
3,5,9,19,20 * 21
18,19 * 21 |
Sugar
Sugar |
22.3 percent target mRNA inhibition | 19282453 |
| SM0556 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
19,20 * 21
18,19 * 21 |
Sugar
Sugar |
53.1 percent target mRNA inhibition | 19282453 |
| SM0557 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
2-Aminopropoxymethyl* 2-Deoxy |
3,5,9,19,20 * 21
18,19 * 21 |
Sugar
Sugar |
7.7 percent target mRNA inhibition | 19282453 |
| SM0558 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Oxetane-Locked nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
16,18
18,19 * 21 |
Sugar
Sugar |
57.9 percent target mRNA inhibition | 19282453 |
| SM0559 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Oxetane-Locked nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
2,4
18,19 * 21 |
Sugar
Sugar |
43.5 percent target mRNA inhibition | 19282453 |
| SM0560 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Fluoro* 2-O-Methyl
2-Aminopropoxymethyl* 2-Deoxy |
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
18,19 * 21 |
Sugar
Sugar |
26.3 percent target mRNA inhibition | 19282453 |
| SM0561 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
2-Aminopropoxymethyl* 2-Deoxy |
20
18,19 * 21 |
Sugar
Sugar |
42.7 percent target mRNA inhibition | 19282453 |
| SM0562 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
2-Aminopropoxymethyl* 2-Deoxy |
19
18,19 * 21 |
Sugar
Sugar |
6 percent target mRNA inhibition | 19282453 |
| SM0563 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
2-Aminopropoxymethyl* 2-Deoxy |
5,19,20
18,19 * 21 |
Sugar
Sugar |
16.1 percent target mRNA inhibition | 19282453 |
| SM0564 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
Locked nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
3,9,15,20,21
18,19 * 21 |
Sugar
Sugar |
7.2 percent target mRNA inhibition | 19282453 |
| SM0565 |
GACGUAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
19,20
18,19 * 21 |
Sugar
Sugar |
25.4 percent target mRNA inhibition | 19282453 |
| SM0566 |
GACGTAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
5,19,20
18,19 * 21 |
Sugar
Sugar |
54.2 percent target mRNA inhibition | 19282453 |