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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxy* 2-Fluoro* 2-Methoxy are 14
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4976
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.29 percent target mRNA inhibition
    22253019
    SM5006
    CACAAUGCAUUUAGAUCAAUU
    TTGATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    34.12 percent target mRNA inhibition
    22253019
    SM5033
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    64.82 percent target mRNA inhibition
    22253019
    SM5066
    UCAUCACACUGAAUACCAAUU
    TTGGTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.97 percent target mRNA inhibition
    22253019
    SM5095
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.73 percent target mRNA inhibition
    22253019
    SM5096
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    67.24 percent target mRNA inhibition
    22253019
    SM5126
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    76.93 percent target mRNA inhibition
    22253019
    SM5156
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.51 percent target mRNA inhibition
    22253019
    SM5186
    CACAAUGCAUUUAGAUCAAUU
    TTGATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    36.81 percent target mRNA inhibition
    22253019
    SM5213
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    22.31 percent target mRNA inhibition
    22253019
    SM5246
    UCAUCACACUGAAUACCAAUU
    TTGGTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    90.36 percent target mRNA inhibition
    22253019
    SM5275
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    91.31 percent target mRNA inhibition
    22253019
    SM5276
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    64.22 percent target mRNA inhibition
    22253019
    SM5306
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    74.7 percent target mRNA inhibition
    22253019