SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3769 |
ACGGCUCGCUACCCUCGACTT GUCGAGGGUAGCGAGCCGUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
10 9 |
Sugar Sugar |
78 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3785 |
AGUAAUCCGGACUCAACUCTT GAGUUGAGUCCGGAUUACUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3,14 5,16 |
Sugar Sugar |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3786 |
AGUAAUCCGGACUCAACUCTT GAGUUGAGUCCGGAUUACUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3 16 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3801 |
GCUGUAACCUCGGAGAGUUTT AACUCUCCGAGGUUACAGCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3,5 14,16 |
Sugar Sugar |
62 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3802 |
GCUGUAACCUCGGAGAGUUTT AACUCUCCGAGGUUACAGCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5 14 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3817 |
AAGUAGUCCCCCUUGAAGATT UCUUCAAGGGGGACUACUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
4,11,14 5,15 |
Sugar Sugar |
64 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3818 |
AAGUAGUCCCCCUUGAAGATT UCUUCAAGGGGGACUACUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5 15 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3832 |
GCCUCUCUAUCCUUAGCUUTT AAGCUAAGGAUAGAGAGGCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
1,3,5,7,9,11,13,15,17 7,12 |
Sugar Sugar |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3833 |
GCCUCUCUAUCCUUAGCUUTT AAGCUAAGGAUAGAGAGGCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5,8,14 5,11 |
Sugar Sugar |
47 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3834 |
GCCUCUCUAUCCUUAGCUUTT AAGCUAAGGAUAGAGAGGCTT |
0 2-Deoxy-2-Fluoro |
0 5,11 |
0 Sugar |
48 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3837 |
AAGGACCUAGAGGAGUCACTT GUGACUCCUCUAGGUCCUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
8,17 2,11 |
Sugar Sugar |
87 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3838 |
AAGGACCUAGAGGAGUCACTT GUGACUCCUCUAGGUCCUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
8 11 |
Sugar Sugar |
88 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3853 |
CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
2,8,12 17 |
Sugar Sugar |
78 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3854 |
CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
2 0 |
Sugar 0 |
81 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3856 |
ACAUAGAGGAAGACGCGGATT UCCGCGUCUUCCUCUAUGUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
1,3,5,7,9,11 1,3,5,7,9,11,13,15,17 |
Sugar Sugar |
57 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3857 |
ACAUAGAGGAAGACGCGGATT UCCGCGUCUUCCUCUAUGUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
2,4,6 15,17 |
Sugar Sugar |
86 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3858 |
ACAUAGAGGAAGACGCGGATT UCCGCGUCUUCCUCUAUGUTT |
0 2-Deoxy-2-Fluoro |
0 15 |
0 Sugar |
89 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3873 |
AGACUAAGCCCAAAAGGGCTT GCCCUUUUGGGCUUAGUCUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5,11 8,14 |
Sugar Sugar |
45 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3874 |
AGACUAAGCCCAAAAGGGCTT GCCCUUUUGGGCUUAGUCUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5 14 |
Sugar Sugar |
47 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3889 |
GGCUUAGUCACUCCUCUUCTT GAAGAGGAGUGACUAAGCCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5,9 10,14 |
Sugar Sugar |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3890 |
GGCUUAGUCACUCCUCUUCTT GAAGAGGAGUGACUAAGCCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
5 14 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3913 |
UUCUAACCGGGCAGCUUCUTT AGAAGCUGCCCGGUUAGAATT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
4,12 7,15 |
Sugar Sugar |
71 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3914 |
UUCUAACCGGGCAGCUUCUTT AGAAGCUGCCCGGUUAGAATT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
4 15 |
Sugar Sugar |
72 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3928 |
AAGGCCAACCGAUACUUCUTT AGAAGUAUCGGUUGGCCUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
1,3,5,7,9,11,13,15,17,19 6,8,12,13,18,19 |
Sugar Sugar |
46 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3929 |
AAGGCCAACCGAUACUUCUTT AGAAGUAUCGGUUGGCCUUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
2,6,13 6,13 |
Sugar Sugar |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |