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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 2-Deoxy-2-Fluoro are 171
Results from 125 - 150

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4014	GGGAGGAUGACAAAGAAGCTT GCUUCUUUGUCAUCCUCCCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	9,12 8	Sugar Sugar	84 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4020	AUCGCUGCUCCUCCUCCUCTT GAGGAGGAGGAGCAGCGAUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 19	Sugar Sugar	39 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4021	AUCGCUGCUCCUCCUCCUCTT GAGGAGGAGGAGCAGCGAUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	6,9,12 13	Sugar Sugar	69 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4022	AUCGCUGCUCCUCCUCCUCTT GAGGAGGAGGAGCAGCGAUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	6 13	Sugar Sugar	71 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4032	CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 1,2,10,19	Sugar Sugar	38 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4033	CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	2,12 7,17	Sugar Sugar	91 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4034	CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT	0 2-Deoxy-2-Fluoro	0 7,17	0 Sugar	95 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4040	CCCUCCCCUGUCCCCGCUUTT AAGCGGGGACAGGGGAGGGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 1,2,9,11,16	Sugar Sugar	41 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4041	CCCUCCCCUGUCCCCGCUUTT AAGCGGGGACAGGGGAGGGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	9,17 10	Sugar Sugar	72 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4056	AAACCCCUAGAGGGCAAGUTT ACUUGCCCUCUAGGGGUUUTT	0 2-Deoxy-2-Fluoro	0 1,3,5,7,9,11,13,15,17,19	0 Sugar	37 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4057	AAACCCCUAGAGGGCAAGUTT ACUUGCCCUCUAGGGGUUUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	8,14 4,11	Sugar Sugar	82 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4060	GGAACCUCACAUCAACGCGCATT UGCGCGUUGAUGUGAGGUUCCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 10,15	Sugar Sugar	21 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4061	GGAACCUCACAUCAACGCGCATT UGCGCGUUGAUGUGAGGUUCCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	8,10,13,20 1,8,11,13	Sugar Sugar	52 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4062	GGAACCUCACAUCAACGCGCATT UGCGCGUUGAUGUGAGGUUCCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	8 2,8,11	Sugar Sugar	65 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4088	AGAAGUACCAGGAGGCGUUTT AACGCCUCCUGGUACUUCUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 4,11,12	Sugar Sugar	39 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4089	AGAAGUACCAGGAGGCGUUTT AACGCCUCCUGGUACUUCUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	6,9 10,13	Sugar Sugar	57 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4090	AGAAGUACCAGGAGGCGUUTT AACGCCUCCUGGUACUUCUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	6 10	Sugar Sugar	60 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4104	CCAGCGAGCCCAAAAGAAATT UUUCUUUUGGGCUCGCUGGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	4,6,8,16 1,3,5,7,9,11,13,15,17,19	Sugar Sugar	35 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4105	CCAGCGAGCCCAAAAGAAATT UUUCUUUUGGGCUCGCUGGTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	2,11,16 8,17	Sugar Sugar	82 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4128	GCUUCGGAAACUGGACAUCTT GAUGUCCAGUUUCCGAAGCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 1,4,9,15,18	Sugar Sugar	29 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4129	GCUUCGGAAACUGGACAUCTT GAUGUCCAGUUUCCGAAGCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	12,13,16 3,7,8	Sugar Sugar	87 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4130	GCUUCGGAAACUGGACAUCTT GAUGUCCAGUUUCCGAAGCTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	16 3,7	Sugar Sugar	90 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4132	AACUCUACUGUGGAGUCGGTT CCGACUCCACAGUAGAGUUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	1,3,5,7,9,11,13,15,17,19 3,12,15,17	Sugar Sugar	25 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4133	AACUCUACUGUGGAGUCGGTT CCGACUCCACAGUAGAGUUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	6,9,11 8,10,13	Sugar Sugar	65 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM4134	AACUCUACUGUGGAGUCGGTT CCGACUCCACAGUAGAGUUTT	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	9 8,13	Sugar Sugar	72 percent target mRNA inhibition	US20120088815A1, EP2415869A1



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