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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Methoxy* 2-Fluoro* 2-Hydroxy are 10
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4977
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    94.21 percent target mRNA inhibition
    22253019
    SM5007
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18,20,21* 3,4,8,9,10,12,17,19 * 14
    Base; Sugar; Sugar
    Sugar
    95.77 percent target mRNA inhibition
    22253019
    SM5067
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,17,20,21 * 3,4,6,10,11,13,15,16,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    94.94 percent target mRNA inhibition
    22253019
    SM5097
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,16,17,19,20,21 * 3,5,8,9,10,11,15,18 * 14
    Base; Sugar; Sugar
    Sugar
    89.08 percent target mRNA inhibition
    22253019
    SM5127
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Sugar
    91.78 percent target mRNA inhibition
    22253019
    SM5157
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    95.94 percent target mRNA inhibition
    22253019
    SM5187
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18,20,21* 3,4,8,9,10,12,17,19 * 14
    Base; Sugar; Sugar
    Sugar
    96.92 percent target mRNA inhibition
    22253019
    SM5247
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,17,20,21 * 3,4,6,10,11,13,15,16,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    89.54 percent target mRNA inhibition
    22253019
    SM5277
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,16,17,19,20,21 * 3,5,8,9,10,11,15,18 * 14
    Base; Sugar; Sugar
    Sugar
    84.46 percent target mRNA inhibition
    22253019
    SM5307
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Sugar
    87.07 percent target mRNA inhibition
    22253019