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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid are 90
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1533
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    48.5 percent target mRNA inhibition
    19282453
    SM1534
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    47.1 percent target mRNA inhibition
    19282453
    SM1535
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,8,14,17
    6 * 20,21
    Sugar
    Sugar
    30.6 percent target mRNA inhibition
    19282453
    SM1536
    GACGUAAACGGCCACAAGUUCT
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,8,14,17,22
    6 * 20,21
    Sugar
    Sugar
    21.4 percent target mRNA inhibition
    19282453
    SM1537
    GACGUAAACGGCCACAAGUUCT
    ACUUGTGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,2 * 22
    6 * 20,21
    Sugar
    Sugar
    34.6 percent target mRNA inhibition
    19282453
    SM1538
    GACGUAAACGGCCACAAGUUCT
    ACUUGTGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18,19 * 22
    6 * 20,21
    Sugar
    Sugar
    37.2 percent target mRNA inhibition
    19282453
    SM1539
    GACGUAAACGGCCACAAGUUCT
    ACUUGTGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,8,11,14,17 * 22
    6 * 20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM1540
    GACGUAAACGGCCACAAGUUCU
    ACUUGTGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20,21
    6 * 20,21
    Sugar
    Sugar
    19.9 percent target mRNA inhibition
    19282453
    SM1541
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19,20
    6 * 20,21
    Sugar
    Sugar
    42.2 percent target mRNA inhibition
    19282453
    SM1542
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,2,3,18,19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    41.4 percent target mRNA inhibition
    19282453
    SM1543
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,8,11,14 * 21
    6 * 20,21
    Sugar
    Sugar
    24.9 percent target mRNA inhibition
    19282453
    SM1544
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,8,11,14,19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    33.2 percent target mRNA inhibition
    19282453
    SM1545
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    45.4 percent target mRNA inhibition
    19282453
    SM1546
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,5,9,19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    29.8 percent target mRNA inhibition
    19282453
    SM1547
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    46 percent target mRNA inhibition
    19282453
    SM1548
    GACGUAAACGGCCACAAGUUT
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,5,9,19,20 * 21
    6 * 20,21
    Sugar
    Sugar
    0.4 percent target mRNA inhibition
    19282453
    SM1549
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    16,18
    6 * 20,21
    Sugar
    Sugar
    31.2 percent target mRNA inhibition
    19282453
    SM1550
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4
    6 * 20,21
    Sugar
    Sugar
    40.1 percent target mRNA inhibition
    19282453
    SM1551
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    6 * 20,21
    Sugar
    Sugar
    12.7 percent target mRNA inhibition
    19282453
    SM1552
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20
    6 * 20,21
    Sugar
    Sugar
    49.4 percent target mRNA inhibition
    19282453
    SM1553
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19
    6 * 20,21
    Sugar
    Sugar
    44.8 percent target mRNA inhibition
    19282453
    SM1554
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,19,20
    6 * 20,21
    Sugar
    Sugar
    33 percent target mRNA inhibition
    19282453
    SM1555
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,9,15,20,21
    6 * 20,21
    Sugar
    Sugar
    40.5 percent target mRNA inhibition
    19282453
    SM1556
    GACGUAAACGGCCACAAGTTC
    ACUUGTGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19,20
    6 * 20,21
    Sugar
    Sugar
    26.5 percent target mRNA inhibition
    19282453
    SM1557
    GACGTAAACGGCCACAAGTTC
    ACUUGTGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,19,20
    6 * 20,21
    Sugar
    Sugar
    43.6 percent target mRNA inhibition
    19282453