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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid are 90
    Results from 25 - 50
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1558
    GACGUAAACG + GCCACAAGUTC
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,9,13,15,20,21
    6 * 20,21
    Sugar
    Sugar
    22.1 percent target mRNA inhibition
    19282453
    SM1559
    GACGTAAACGGCCACAAGTTCT
    ACUUGTGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    6 * 20,21
    Sugar
    Sugar
    9.5 percent target mRNA inhibition
    19282453
    SM1560
    GACGTAAACGGCCACAAGTTCT
    ACUUGTGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    6 * 20,21
    Sugar
    Sugar
    4 percent target mRNA inhibition
    19282453
    SM1561
    GACGTAAACGGCCACAAGTTCT
    ACUUGTGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    6 * 20,21
    Sugar
    Sugar
    9.4 percent target mRNA inhibition
    19282453
    SM1562
    GACGTAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,20,21
    6 * 20,21
    Sugar
    Sugar
    45 percent target mRNA inhibition
    19282453
    SM1563
    GACGTAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,5,7,9,20,21
    6 * 20,21
    Sugar
    Sugar
    2.7 percent target mRNA inhibition
    19282453
    SM1564
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,9,13,15,20,21
    6 * 20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM1565
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20,21
    6 * 20,21
    Sugar
    Sugar
    53 percent target mRNA inhibition
    19282453
    SM1566
    GACGTAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,5,9,13,20,21
    6 * 20,21
    Sugar
    Sugar
    24.2 percent target mRNA inhibition
    19282453
    SM1567
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20,21
    6 * 20,21
    Sugar
    Sugar
    45.1 percent target mRNA inhibition
    19282453
    SM1568
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,9,15,20,21
    6 * 20,21
    Sugar
    Sugar
    48 percent target mRNA inhibition
    19282453
    SM1569
    GACGUAAACGGCCACAAGUUTU
    ACUUGTGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    46.7 percent target mRNA inhibition
    19282453
    SM1570
    GACGTAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,20 * 21
    6 * 20,21
    Sugar
    Sugar
    41 percent target mRNA inhibition
    19282453
    SM1571
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5 * 20,21
    6 * 20,21
    Sugar
    Sugar
    29.7 percent target mRNA inhibition
    19282453
    SM1572
    GACGUAAACCGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    10 * 21,22
    6 * 20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM1573
    GACGUAAACGGCCACAAGUUUU
    ACUUGTGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    48.1 percent target mRNA inhibition
    19282453
    SM1574
    GACGUAAACGGCCACAAGUUUU
    ACUUGTGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,21
    6 * 20,21
    Sugar
    Sugar
    36.1 percent target mRNA inhibition
    19282453
    SM1575
    GACGUAAACGGCCACAAGUTCU
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    3,8,13,15,20,21
    6 * 20,21
    Sugar
    Sugar
    10.1 percent target mRNA inhibition
    19282453
    SM1576
    GACGUAAACGGCCACAAGUTC
    ACUUGTGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20,21
    6 * 20,21
    Sugar
    Sugar
    51.9 percent target mRNA inhibition
    19282453
    SM1577
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    0
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    0
    6 * 20,21
    0
    Sugar
    45.9 percent target mRNA inhibition
    19282453
    SM1623
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    77.7 percent target mRNA inhibition
    19282453
    SM1624
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Guanidinoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    72.5 percent target mRNA inhibition
    19282453
    SM1625
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    Hexitol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,8,14,17
    18 * 20,21
    Sugar
    Sugar
    17.5 percent target mRNA inhibition
    19282453
    SM1626
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGTCGCU
    Hexitol nucleic acid
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,8,14,17,22
    18 * 20,21
    Sugar
    Sugar
    10.5 percent target mRNA inhibition
    19282453
    SM1627
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGTCGCU
    Altritol nucleic acid* 2-Deoxy
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    1,2 * 22
    18 * 20,21
    Sugar
    Sugar
    69.6 percent target mRNA inhibition
    19282453