| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM1308 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
18
19,21 |
Sugar
Sugar |
89.8 percent target mRNA inhibition | 19282453 |
| SM1309 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Guanidinoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
18
19,21 |
Sugar
Sugar |
84.7 percent target mRNA inhibition | 19282453 |
| SM1310 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
2,8,14,17
19,21 |
Sugar
Sugar |
73.1 percent target mRNA inhibition | 19282453 |
| SM1311 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,14,17,22
19,21 |
Sugar
Sugar |
48.1 percent target mRNA inhibition | 19282453 |
| SM1312 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2 * 22
19,21 |
Sugar
Sugar |
84.4 percent target mRNA inhibition | 19282453 |
| SM1313 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
18,19 * 22
19,21 |
Sugar
Sugar |
86.6 percent target mRNA inhibition | 19282453 |
| SM1314 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,11,14,17 * 22
19,21 |
Sugar
Sugar |
58.4 percent target mRNA inhibition | 19282453 |
| SM1315 |
GACGUAAACGGCCACAAGUUCU
ACUUGUGGCCGUUUACGUCGCU |
Altritol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
19,21 |
Sugar
Sugar |
82 percent target mRNA inhibition | 19282453 |
| SM1316 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20
19,21 |
Sugar
Sugar |
91.1 percent target mRNA inhibition | 19282453 |
| SM1317 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2,3,18,19,20 * 21
19,21 |
Sugar
Sugar |
83.7 percent target mRNA inhibition | 19282453 |
| SM1318 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,11,14 * 21
19,21 |
Sugar
Sugar |
68.7 percent target mRNA inhibition | 19282453 |
| SM1319 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
Hexitol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,11,14,19,20 * 21
19,21 |
Sugar
Sugar |
82.5 percent target mRNA inhibition | 19282453 |
| SM1320 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20 * 21
19,21 |
Sugar
Sugar |
84.8 percent target mRNA inhibition | 19282453 |
| SM1321 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,19,20 * 21
19,21 |
Sugar
Sugar |
85.1 percent target mRNA inhibition | 19282453 |
| SM1322 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20 * 21
19,21 |
Sugar
Sugar |
85.5 percent target mRNA inhibition | 19282453 |
| SM1323 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGCU |
2-Aminopropoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,19,20 * 21
19,21 |
Sugar
Sugar |
80.2 percent target mRNA inhibition | 19282453 |
| SM1324 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
Oxetane-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
16,18
19,21 |
Sugar
Sugar |
86.2 percent target mRNA inhibition | 19282453 |
| SM1325 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
Oxetane-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
2,4
19,21 |
Sugar
Sugar |
79.3 percent target mRNA inhibition | 19282453 |
| SM1326 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Fluoro* 2-O-Methyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
19,21 |
Sugar
Sugar |
69.7 percent target mRNA inhibition | 19282453 |
| SM1327 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
20
19,21 |
Sugar
Sugar |
84.8 percent target mRNA inhibition | 19282453 |
| SM1328 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
19
19,21 |
Sugar
Sugar |
85.4 percent target mRNA inhibition | 19282453 |
| SM1329 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,19,20
19,21 |
Sugar
Sugar |
76.6 percent target mRNA inhibition | 19282453 |
| SM1330 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,15,20,21
19,21 |
Sugar
Sugar |
81.9 percent target mRNA inhibition | 19282453 |
| SM1331 |
GACGUAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20
19,21 |
Sugar
Sugar |
84 percent target mRNA inhibition | 19282453 |
| SM1332 |
GACGTAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,19,20
19,21 |
Sugar
Sugar |
83.7 percent target mRNA inhibition | 19282453 |