| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM1333 |
GACGUAAACG + GCCACAAGUTC
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,13,15,20,21
19,21 |
Sugar
Sugar |
83.4 percent target mRNA inhibition | 19282453 |
| SM1334 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGCU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
19,21 |
Sugar
Sugar |
36.7 percent target mRNA inhibition | 19282453 |
| SM1335 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGCU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
19,21 |
Sugar
Sugar |
41.3 percent target mRNA inhibition | 19282453 |
| SM1336 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGCU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
19,21 |
Sugar
Sugar |
14.4 percent target mRNA inhibition | 19282453 |
| SM1337 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,20,21
19,21 |
Sugar
Sugar |
83.8 percent target mRNA inhibition | 19282453 |
| SM1338 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,7,9,20,21
19,21 |
Sugar
Sugar |
49.6 percent target mRNA inhibition | 19282453 |
| SM1339 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,13,15,20,21
19,21 |
Sugar
Sugar |
67.4 percent target mRNA inhibition | 19282453 |
| SM1340 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
19,21 |
Sugar
Sugar |
87.9 percent target mRNA inhibition | 19282453 |
| SM1341 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,13,20,21
19,21 |
Sugar
Sugar |
82.9 percent target mRNA inhibition | 19282453 |
| SM1342 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Alfa-L-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
19,21 |
Sugar
Sugar |
85.7 percent target mRNA inhibition | 19282453 |
| SM1343 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Alfa-L-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,15,20,21
19,21 |
Sugar
Sugar |
84.9 percent target mRNA inhibition | 19282453 |
| SM1344 |
GACGUAAACGGCCACAAGUUTU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
21
19,21 |
Sugar
Sugar |
85.9 percent target mRNA inhibition | 19282453 |
| SM1345 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,20 * 21
19,21 |
Sugar
Sugar |
74.9 percent target mRNA inhibition | 19282453 |
| SM1346 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5 * 20,21
19,21 |
Sugar
Sugar |
79.2 percent target mRNA inhibition | 19282453 |
| SM1347 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
10 * 21,22
19,21 |
Sugar
Sugar |
63.7 percent target mRNA inhibition | 19282453 |
| SM1348 |
GACGUAAACGGCCACAAGUUUU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
21
19,21 |
Sugar
Sugar |
87.7 percent target mRNA inhibition | 19282453 |
| SM1349 |
GACGUAAACGGCCACAAGUUUU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,21
19,21 |
Sugar
Sugar |
82.5 percent target mRNA inhibition | 19282453 |
| SM1350 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,8,13,15,20,21
19,21 |
Sugar
Sugar |
69.8 percent target mRNA inhibition | 19282453 |
| SM1351 |
GACGUAAACGGCCACAAGUTC
ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
19,21 |
Sugar
Sugar |
84 percent target mRNA inhibition | 19282453 |
| SM1352 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGCU |
0
4-C-Hydroxymethyl Deoxyribonucleic acid |
0
19,21 |
0
Sugar |
82.2 percent target mRNA inhibition | 19282453 |
| SM1443 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCTTU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
18
20,21 |
Sugar
Sugar |
56.4 percent target mRNA inhibition | 19282453 |
| SM1444 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCTTU |
2-Guanidinoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
18
20,21 |
Sugar
Sugar |
62.9 percent target mRNA inhibition | 19282453 |
| SM1445 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCTTU |
Hexitol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
2,8,14,17
20,21 |
Sugar
Sugar |
57.5 percent target mRNA inhibition | 19282453 |
| SM1446 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCTTU |
Hexitol nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,14,17,22
20,21 |
Sugar
Sugar |
30.9 percent target mRNA inhibition | 19282453 |
| SM1447 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCTTU |
Altritol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2 * 22
20,21 |
Sugar
Sugar |
66.9 percent target mRNA inhibition | 19282453 |