| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM1498 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
Hexitol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,11,14 * 21
21 |
Sugar
Sugar |
66.2 percent target mRNA inhibition | 19282453 |
| SM1499 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
Hexitol nucleic acid* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,8,11,14,19,20 * 21
21 |
Sugar
Sugar |
77 percent target mRNA inhibition | 19282453 |
| SM1500 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
2-Aminoethoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20 * 21
21 |
Sugar
Sugar |
78.7 percent target mRNA inhibition | 19282453 |
| SM1501 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
2-Aminoethoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,19,20 * 21
21 |
Sugar
Sugar |
79.2 percent target mRNA inhibition | 19282453 |
| SM1502 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
2-Aminopropoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20 * 21
21 |
Sugar
Sugar |
80.8 percent target mRNA inhibition | 19282453 |
| SM1503 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGTU |
2-Aminopropoxymethyl* 2-Deoxy
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,19,20 * 21
21 |
Sugar
Sugar |
75.3 percent target mRNA inhibition | 19282453 |
| SM1504 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
Oxetane-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
16,18
21 |
Sugar
Sugar |
83.5 percent target mRNA inhibition | 19282453 |
| SM1505 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
Oxetane-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
2,4
21 |
Sugar
Sugar |
74.4 percent target mRNA inhibition | 19282453 |
| SM1506 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
2-Fluoro* 2-O-Methyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
21 |
Sugar
Sugar |
71.6 percent target mRNA inhibition | 19282453 |
| SM1507 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
20
21 |
Sugar
Sugar |
79.3 percent target mRNA inhibition | 19282453 |
| SM1508 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
19
21 |
Sugar
Sugar |
77.6 percent target mRNA inhibition | 19282453 |
| SM1509 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGTU |
2-Aminoethyl
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,19,20
21 |
Sugar
Sugar |
69.9 percent target mRNA inhibition | 19282453 |
| SM1510 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,15,20,21
21 |
Sugar
Sugar |
76.7 percent target mRNA inhibition | 19282453 |
| SM1511 |
GACGUAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGTU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
19,20
21 |
Sugar
Sugar |
77.4 percent target mRNA inhibition | 19282453 |
| SM1512 |
GACGTAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGTU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,19,20
21 |
Sugar
Sugar |
84.1 percent target mRNA inhibition | 19282453 |
| SM1513 |
GACGUAAACG + GCCACAAGUTC
ACUUGUGGCCGUUUACGUCGTU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,13,15,20,21
21 |
Sugar
Sugar |
73.5 percent target mRNA inhibition | 19282453 |
| SM1514 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGTU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
21 |
Sugar
Sugar |
16.1 percent target mRNA inhibition | 19282453 |
| SM1515 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGTU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
21 |
Sugar
Sugar |
38.6 percent target mRNA inhibition | 19282453 |
| SM1516 |
GACGTAAACGGCCACAAGTTCT
ACUUGUGGCCGUUUACGUCGTU |
2-Deoxy* Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
21 |
Sugar
Sugar |
14.7 percent target mRNA inhibition | 19282453 |
| SM1517 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
5,20,21
21 |
Sugar
Sugar |
77.2 percent target mRNA inhibition | 19282453 |
| SM1518 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,7,9,20,21
21 |
Sugar
Sugar |
51.1 percent target mRNA inhibition | 19282453 |
| SM1519 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,9,13,15,20,21
21 |
Sugar
Sugar |
60.9 percent target mRNA inhibition | 19282453 |
| SM1520 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
21 |
Sugar
Sugar |
87.8 percent target mRNA inhibition | 19282453 |
| SM1521 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
4-C-Hydroxymethyl Deoxyribonucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
3,5,9,13,20,21
21 |
Sugar
Sugar |
73.3 percent target mRNA inhibition | 19282453 |
| SM1522 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGTU |
Alfa-L-Locked nucleic acid
4-C-Hydroxymethyl Deoxyribonucleic acid |
20,21
21 |
Sugar
Sugar |
78.8 percent target mRNA inhibition | 19282453 |