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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 5-phosphate ribose* 2-Methoxy* 2-Hydroxy are 10
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4991	CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	91.97 percent target mRNA inhibition	22253019
SM5021	CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	97.78 percent target mRNA inhibition	22253019
SM5051	UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	95.91 percent target mRNA inhibition	22253019
SM5081	ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	88.27 percent target mRNA inhibition	22253019
SM5111	AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	79.02 percent target mRNA inhibition	22253019
SM5171	CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	95.14 percent target mRNA inhibition	22253019
SM5201	CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	92.56 percent target mRNA inhibition	22253019
SM5231	UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	94.42 percent target mRNA inhibition	22253019
SM5261	ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	88.19 percent target mRNA inhibition	22253019
SM5291	AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU	Inverted abasic* 2-Deoxy* 2-Methoxy 5-phosphate ribose* 2-Methoxy* 2-Hydroxy	1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14	Base; Sugar; Sugar Phosphate; Sugar; Sugar	72.84 percent target mRNA inhibition	22253019