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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 347
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1218
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Locked nucleic acid
    18
    20,21
    Sugar
    Sugar
    91.1 percent target mRNA inhibition
    19282453
    SM1219
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Locked nucleic acid
    18
    20,21
    Sugar
    Sugar
    88.4 percent target mRNA inhibition
    19282453
    SM1220
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Locked nucleic acid
    2,8,14,17
    20,21
    Sugar
    Sugar
    81.7 percent target mRNA inhibition
    19282453
    SM1221
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Locked nucleic acid
    5,8,14,17,22
    20,21
    Sugar
    Sugar
    90.5 percent target mRNA inhibition
    19282453
    SM1222
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    Locked nucleic acid
    1,2 * 22
    20,21
    Sugar
    Sugar
    90.8 percent target mRNA inhibition
    19282453
    SM1223
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    Locked nucleic acid
    18,19 * 22
    20,21
    Sugar
    Sugar
    85 percent target mRNA inhibition
    19282453
    SM1224
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    Locked nucleic acid
    5,8,11,14,17 * 22
    20,21
    Sugar
    Sugar
    88.2 percent target mRNA inhibition
    19282453
    SM1225
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    90.4 percent target mRNA inhibition
    19282453
    SM1226
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Locked nucleic acid
    19,20
    20,21
    Sugar
    Sugar
    90 percent target mRNA inhibition
    19282453
    SM1227
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Locked nucleic acid
    1,2,3,18,19,20 * 21
    20,21
    Sugar
    Sugar
    87.3 percent target mRNA inhibition
    19282453
    SM1228
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Locked nucleic acid
    5,8,11,14 * 21
    20,21
    Sugar
    Sugar
    90 percent target mRNA inhibition
    19282453
    SM1229
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Locked nucleic acid
    5,8,11,14,19,20 * 21
    20,21
    Sugar
    Sugar
    90.4 percent target mRNA inhibition
    19282453
    SM1230
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    Locked nucleic acid
    19,20 * 21
    20,21
    Sugar
    Sugar
    90.9 percent target mRNA inhibition
    19282453
    SM1231
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    Locked nucleic acid
    3,5,9,19,20 * 21
    20,21
    Sugar
    Sugar
    90.8 percent target mRNA inhibition
    19282453
    SM1232
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    Locked nucleic acid
    19,20 * 21
    20,21
    Sugar
    Sugar
    87.6 percent target mRNA inhibition
    19282453
    SM1233
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    Locked nucleic acid
    3,5,9,19,20 * 21
    20,21
    Sugar
    Sugar
    90.6 percent target mRNA inhibition
    19282453
    SM1234
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Locked nucleic acid
    16,18
    20,21
    Sugar
    Sugar
    90.5 percent target mRNA inhibition
    19282453
    SM1235
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Locked nucleic acid
    2,4
    20,21
    Sugar
    Sugar
    90.6 percent target mRNA inhibition
    19282453
    SM1236
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    Locked nucleic acid
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1237
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Locked nucleic acid
    20
    20,21
    Sugar
    Sugar
    90.9 percent target mRNA inhibition
    19282453
    SM1238
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Locked nucleic acid
    19
    20,21
    Sugar
    Sugar
    91 percent target mRNA inhibition
    19282453
    SM1239
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Locked nucleic acid
    5,19,20
    20,21
    Sugar
    Sugar
    91.6 percent target mRNA inhibition
    19282453
    SM1240
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,15,20,21
    20,21
    Sugar
    Sugar
    87.1 percent target mRNA inhibition
    19282453
    SM1241
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Locked nucleic acid
    19,20
    20,21
    Sugar
    Sugar
    91.8 percent target mRNA inhibition
    19282453
    SM1242
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    90.9 percent target mRNA inhibition
    19282453