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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Phosphorothioate* 2-Deoxy-2-fluororibose are 19
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4327
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    29 percent target mRNA inhibition
    15974578
    SM4328
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    28 percent target mRNA inhibition
    15974578
    SM4329
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    34 percent target mRNA inhibition
    15974578
    SM4330
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    43 percent target mRNA inhibition
    15974578
    SM4331
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    40 percent target mRNA inhibition
    15974578
    SM4332
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    34 percent target mRNA inhibition
    15974578
    SM4333
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    33 percent target mRNA inhibition
    15974578
    SM4334
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    68 percent target mRNA inhibition
    15974578
    SM4335
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    62 percent target mRNA inhibition
    15974578
    SM4336
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    75 percent target mRNA inhibition
    15974578
    SM4337
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    83 percent target mRNA inhibition
    15974578
    SM4338
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    68 percent target mRNA inhibition
    15974578
    SM4339
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    80 percent target mRNA inhibition
    15974578
    SM4340
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    72 percent target mRNA inhibition
    15974578
    SM4781
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 15,16,17
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.3 nM for target mRNA
    US 8394947 B2
    SM4782
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 12,13,14
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.30815 nM for target mRNA
    US 8394947 B2
    SM4783
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 6,7,8
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.5416 nM for target mRNA
    US 8394947 B2
    SM4784
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 18,19,20
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.0933 nM for target mRNA
    US 8394947 B2
    SM4785
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.68552 nM for target mRNA
    US 8394947 B2