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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Phosphorothioate* 2-O-(2-methoxyethyl)ribose are 14
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4341
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    4 percent target mRNA inhibition
    15974578
    SM4342
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    10 percent target mRNA inhibition
    15974578
    SM4343
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    20 percent target mRNA inhibition
    15974578
    SM4344
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    30 percent target mRNA inhibition
    15974578
    SM4345
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    15 percent target mRNA inhibition
    15974578
    SM4346
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    20 percent target mRNA inhibition
    15974578
    SM4347
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    10 percent target mRNA inhibition
    15974578
    SM4348
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    15 percent target mRNA inhibition
    15974578
    SM4349
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    20 percent target mRNA inhibition
    15974578
    SM4350
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    45 percent target mRNA inhibition
    15974578
    SM4351
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    50 percent target mRNA inhibition
    15974578
    SM4352
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    36 percent target mRNA inhibition
    15974578
    SM4353
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    44 percent target mRNA inhibition
    15974578
    SM4354
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    17 percent target mRNA inhibition
    15974578