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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Phosphorothioate* Locked nucleic acid are 3
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4765	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Locked nucleic acid	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11	0 Phosphate-linkage; Sugar	IC-50 = 0.5627 nM for target mRNA	US 8394947 B2
SM4766	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Locked nucleic acid	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 18,19,20	0 Phosphate-linkage; Sugar	IC-50 = 0.27688 nM for target mRNA	US 8394947 B2
SM4767	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Locked nucleic acid	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 19	0 Phosphate-linkage; Sugar	IC-50 = 5.58 nM for target mRNA	US 8394947 B2