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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Unlocked nucleic acid are 133
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1983	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid	18 21	Sugar Sugar	86 percent target mRNA inhibition	19282453
SM1984	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Unlocked nucleic acid	18 21	Sugar Sugar	78.8 percent target mRNA inhibition	19282453
SM1985	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid	2,8,14,17 21	Sugar Sugar	65.3 percent target mRNA inhibition	19282453
SM1986	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid	5,8,14,17,22 21	Sugar Sugar	16.5 percent target mRNA inhibition	19282453
SM1987	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid	1,2 * 22 21	Sugar Sugar	74.6 percent target mRNA inhibition	19282453
SM1988	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid	18,19 * 22 21	Sugar Sugar	79.1 percent target mRNA inhibition	19282453
SM1989	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid	5,8,11,14,17 * 22 21	Sugar Sugar	38.6 percent target mRNA inhibition	19282453
SM1990	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Unlocked nucleic acid	20,21 21	Sugar Sugar	72 percent target mRNA inhibition	19282453
SM1991	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid	19,20 21	Sugar Sugar	84.2 percent target mRNA inhibition	19282453
SM1992	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid	1,2,3,18,19,20 * 21 21	Sugar Sugar	78.2 percent target mRNA inhibition	19282453
SM1993	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid	5,8,11,14 * 21 21	Sugar Sugar	52.8 percent target mRNA inhibition	19282453
SM1994	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid	5,8,11,14,19,20 * 21 21	Sugar Sugar	73.3 percent target mRNA inhibition	19282453
SM1995	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminoethoxymethyl* 2-Deoxy Unlocked nucleic acid	19,20 * 21 21	Sugar Sugar	78 percent target mRNA inhibition	19282453
SM1996	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminoethoxymethyl* 2-Deoxy Unlocked nucleic acid	3,5,9,19,20 * 21 21	Sugar Sugar	78.1 percent target mRNA inhibition	19282453
SM1997	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminopropoxymethyl* 2-Deoxy Unlocked nucleic acid	19,20 * 21 21	Sugar Sugar	80 percent target mRNA inhibition	19282453
SM1998	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminopropoxymethyl* 2-Deoxy Unlocked nucleic acid	3,5,9,19,20 * 21 21	Sugar Sugar	71.3 percent target mRNA inhibition	19282453
SM1999	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Unlocked nucleic acid	16,18 21	Sugar Sugar	85.7 percent target mRNA inhibition	19282453
SM2000	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Unlocked nucleic acid	2,4 21	Sugar Sugar	72.4 percent target mRNA inhibition	19282453
SM2001	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Fluoro* 2-O-Methyl Unlocked nucleic acid	1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 21	Sugar Sugar	73.8 percent target mRNA inhibition	19282453
SM2002	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid	20 21	Sugar Sugar	77.9 percent target mRNA inhibition	19282453
SM2003	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid	19 21	Sugar Sugar	77.7 percent target mRNA inhibition	19282453
SM2004	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid	5,19,20 21	Sugar Sugar	72.2 percent target mRNA inhibition	19282453
SM2005	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,15,20,21 21	Sugar Sugar	76.3 percent target mRNA inhibition	19282453
SM2006	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid	19,20 21	Sugar Sugar	74.5 percent target mRNA inhibition	19282453
SM2007	GACGTAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid	5,19,20 21	Sugar Sugar	82.7 percent target mRNA inhibition	19282453



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