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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Unlocked nucleic acid* Locked nucleic acid are 191
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1803	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid* Locked nucleic acid	18 6 * 20,21	Sugar Sugar	85.4 percent target mRNA inhibition	19282453
SM1804	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Unlocked nucleic acid* Locked nucleic acid	18 6 * 20,21	Sugar Sugar	90.7 percent target mRNA inhibition	19282453
SM1805	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid* Locked nucleic acid	2,8,14,17 6 * 20,21	Sugar Sugar	89.9 percent target mRNA inhibition	19282453
SM1806	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid* Locked nucleic acid	5,8,14,17,22 6 * 20,21	Sugar Sugar	82.5 percent target mRNA inhibition	19282453
SM1807	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	1,2 * 22 6 * 20,21	Sugar Sugar	88 percent target mRNA inhibition	19282453
SM1808	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	18,19 * 22 6 * 20,21	Sugar Sugar	88.2 percent target mRNA inhibition	19282453
SM1809	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	5,8,11,14,17 * 22 6 * 20,21	Sugar Sugar	82.5 percent target mRNA inhibition	19282453
SM1810	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Unlocked nucleic acid* Locked nucleic acid	20,21 6 * 20,21	Sugar Sugar	86.4 percent target mRNA inhibition	19282453
SM1811	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Unlocked nucleic acid* Locked nucleic acid	19,20 6 * 20,21	Sugar Sugar	90.2 percent target mRNA inhibition	19282453
SM1812	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	1,2,3,18,19,20 * 21 6 * 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1813	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	5,8,11,14 * 21 6 * 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1814	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	5,8,11,14,19,20 * 21 6 * 20,21	Sugar Sugar	88.9 percent target mRNA inhibition	19282453
SM1815	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminoethoxymethyl* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	19,20 * 21 6 * 20,21	Sugar Sugar	89.3 percent target mRNA inhibition	19282453
SM1816	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminoethoxymethyl* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	3,5,9,19,20 * 21 6 * 20,21	Sugar Sugar	89.2 percent target mRNA inhibition	19282453
SM1817	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminopropoxymethyl* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	19,20 * 21 6 * 20,21	Sugar Sugar	90.2 percent target mRNA inhibition	19282453
SM1818	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGCU	2-Aminopropoxymethyl* 2-Deoxy Unlocked nucleic acid* Locked nucleic acid	3,5,9,19,20 * 21 6 * 20,21	Sugar Sugar	87.7 percent target mRNA inhibition	19282453
SM1819	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	16,18 6 * 20,21	Sugar Sugar	91 percent target mRNA inhibition	19282453
SM1820	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Oxetane-Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	2,4 6 * 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1821	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Fluoro* 2-O-Methyl Unlocked nucleic acid* Locked nucleic acid	1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 6 * 20,21	Sugar Sugar	89.7 percent target mRNA inhibition	19282453
SM1822	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid* Locked nucleic acid	20 6 * 20,21	Sugar Sugar	90.3 percent target mRNA inhibition	19282453
SM1823	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid* Locked nucleic acid	19 6 * 20,21	Sugar Sugar	89.6 percent target mRNA inhibition	19282453
SM1824	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Aminoethyl Unlocked nucleic acid* Locked nucleic acid	5,19,20 6 * 20,21	Sugar Sugar	90 percent target mRNA inhibition	19282453
SM1825	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,15,20,21 6 * 20,21	Sugar Sugar	89.7 percent target mRNA inhibition	19282453
SM1826	GACGUAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	19,20 6 * 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1827	GACGTAAACGGCCACAAGTTC ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	5,19,20 6 * 20,21	Sugar Sugar	93.4 percent target mRNA inhibition	19282453



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